Corneal blindness is a significant problem treated primarily by corneal transplants. Donor tissue supply is low, creating a growing need for an alternative. A tissue-engineered cornea made from patient-derived cells and biopolymer scaffold materials would be widely accessible to all patients and would alleviate the need for donor sources. Previous work in this lab led to a method for electrospi...

PURPOSE To quantify the error introduced by videokeratographic corneal topography devices in using a paraxial formula to calculate power over the entire corneal surface, including areas removed from the central paraxial region where the formula is known to be invalid. METHODS Corneal refractive power and two paraxial power approximations were computed as a function of distance from the apex f...

Orthogonal and parallel arrays of microfibril bundles are described in the corneal stroma of embryonic and adult chickens. The arrays lie parallel to the corneal surface and are distributed in the extracellular matrix between Bowman's layer and Descemet's membrane. The individual microfibril bundles measure 0.1-0.25 micron in diameter and consist of 20-30 "tubular" rods, of approximately 15 nm ...

Corneal transparency is dependent upon the development of an organized extracellular matrix containing small diameter collagen fibrils with regular spacing, organized as orthogonal lamellae. Proteoglycan-collagen interactions have been implicated in the regulation of collagen fibrillogenesis and matrix assembly. To determine the role of dermatan sulfate proteoglycan in the development and organ...

AIMS/BACKGROUND To describe a bilateral, mid peripheral, ring-shaped corneal opacity, not resembling any known corneal degeneration, dystrophy, or other disorder, and occurring without ocular or systemic disease. METHODS Ophthalmic examination, haematological screening, and ultrasound biomicroscopy. RESULTS A 25 year old man showed grey-white, granular opacities in both corneas, with an 8 m...

Corneal transparency is dependent upon the development of an organized extracellular matrix containing small diameter collagen fibrils with regular spacing, organized as orthogonal lamellae. Proteoglycan-collagen interactions have been implicated in the regulation of collagen fibrillogenesis and matrix assembly. To determine the role of dermatan sulfate proteoglycan in the development and organ...

Results. For the spherical surface, both curvature-based paraxial power approximations were uniform over the entire surface because curvature is constant. However, the corneal refractive power increased from center to periphery, demonstrating the known phenomenon of spherical aberration. For the ellipsoids, which have been shown to model the human cornea, curvature-based power approximations de...

OBJECTIVE To evaluate the effects of the intrastromal corneal ring, a device developed to reduce myopia, on corneal asphericity in a large set of eye bank eyes. METHODS Forty-one deturgesced eye bank eyes were implanted with intrastromal corneal rings of five different thicknesses, ranging from 0.25 mm to 0.45 mm. Corneal asphericity, before and after implantation, was examined using two diff...

This study investigated changes in collagen fibril architecture and the sulphation status of keratan sulphate (KS) glycosaminoglycan (GAG) epitopes from central to peripheral corneal regions. Freshly excised adult bovine corneal tissue was examined as a function of radial position from the centre of the cornea outwards. Corneal thickness, tissue hydration, hydroxyproline content, and the total ...

Corneal transplantation is the most frequently performed type of tissue grafting (George & Larkin, 2004). It is a highly successful treatment of severe corneal disease. However, transplantation of tissue and organs in humans has a major setback: availability of donors. To solve this, there are currently many studies on the possible use of the pig as a source of hearts, kidneys, livers, Islets o...