The integrity of innermost layer the cornea, corneal endothelium, is key to sustaining transparency. Therefore, disease or injury causing loss damage endothelial cell population may threaten vision. Transplantation tissue standard treatment used replace malfunctioning cells. However, this surgery dependent upon donor tissue, which limited in supply. Hence, engineers have attempted construct alt...

In their excellent study, Sahin et al. investigated the effect of diabetes mellitus on various corneal biomechanical parameters, as measured by the Ocular Response Analyzer (ORA; Reichert, Inc., Depew, NY). The rationale of their study is very interesting. To my surprise, the authors showed a decrease in corneal hysteresis (CH) rather than the expected increase. Several factors suggest that dia...

A new Brillouin spectro-microscope was designed and built to investigate the mechanical properties of bovine and human corneas. This instrument integrates a single-stage virtually imaged phased array spectrometer with a novel adaptive-optics interferometric filter to achieve unprecedented rejection of the elastic background signal. As a result, highly-resolved, reproducible data from both thin ...

Keratoconus is a bilateral, non-inflammatory, degenerative corneal disease. The occurrence and development of keratoconus is associated with corneal thinning and conical protrusion, which causes irregular astigmatism. With the disruption of the collagen organization, the cornea loses its shape and function resulting in progressive visual degradation. Currently, corneal topography is the most im...

Abstract In surgical refractive interventions over-correction or under-correction still occur in 10-15 % of cases. Improved outcomes could be achieved by incorporating patient-specific corneal biomechanics into planning. As a first step, this study mechanically characterizes and numerically simulates lenticules harvested during intervention called Corneal Lenticule Extraction for Advanced Refra...

PURPOSE To compare corneal biomechanical properties following three different transplantation techniques, including Descemet stripping automated endothelial keratoplasty (DSAEK), deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in comparison to normal eyes. METHODS This cross-sectional comparative study included 118 eyes: 17 eyes of 17 patients received DSAEK, 23 e...

INTRODUCTION Astigmatism is a visually disabling refractive error, and at least 15%-20% cataract patients have corneal astigmatism of ≥1.50 diopters (D). One way to correct astigmatism simultaneously during cataract surgery is to place limbal relaxing incisions (LRIs). It is possible, however, that late corneal biomechanics may play an unfavorable role in refractive outcomes over time. Toric in...

BACKGROUND The introduction of corneal cross-linking (CXL) with ultraviolet-A (UVA) and Riboflavin photosensitizer (Vit B2) from Seiler et al., revolutionized the treatment of Keratoconus and other corneal ectatic diseases. Today, the commonly known epithelium off Dresden protocol is in clinical use for the last 15 years with great success and regarded by many as the golden standard. METHODS ...

Purpose The purpose of this study was to clarify correlations between corneal deformation parameters measured with a dynamic Scheimpflug analyzer and baseline factors such as axial length, intraocular pressure (IOP), age, central corneal thickness (CCT), and corneal curvature. Methods Ninety-six eyes of 96 healthy subjects (mean 55.2 ± 16.1 years of age) were examined using a dynamic Scheimpf...