Recent studies suggest that exogenously administered CO is beneficial for the resolution of acute inflammation. In this study, we assessed the role of CO liberated from a systemically administered tricarbonyldichlororuthenium-(II)-dimer (CORM-2) on modulation of liver inflammation during sepsis. Polymicrobial sepsis in mice was induced by cecal ligation and perforation (CLP). CORM-2 (8 mg/kg iv...

AIMS Carbon monoxide-releasing molecules (CORMs) are being developed with the ultimate goal of safely utilizing the therapeutic potential of CO clinically, including applications in antimicrobial therapy. Hemes are generally considered the prime targets of CO and CORMs, so we tested this hypothesis using heme-deficient bacteria, applying cellular, transcriptomic, and biochemical tools. RESULT...

OBJECTIVE To determine whether the CO-releasing molecule -liberated CO attenuates infiltration of leukocytes in the renal tissue of thermally injured mice. MATERIALS AND METHODS Twenty-eight mice were assigned to four groups. Mice in sham group (n=7) were underwent sham thermal injury, whereas mice in burn group (n=7) received 15% total body surface area (TBSA) full-thickness thermal injury. ...

In the present investigation attempts were made to estimate genetic parameters for yield and its components in 315 genotypes of cocoyam collected from thirteen aroid growing districts. Plant height, petiole length, petiole breadth, leaf number, leaf length, leaf breadth, LAI, Inflorescence length, peduncle length, spathe length, spathe breadth, corm length, corm breadth, cormel number, cormel l...

This investigation was carried out to determine the effects of gamma radiation on germination characteristics gladiolus corms. experiment conducted through a factorial design in randomized complete block with three replications. Two factors included cultivars (Red Advance, White Prosperity, Amsterdam, and Rose Supreme) doses (0, 15, 25, 35, 45, 55, 65, 75 Gy). The results showed that corm weigh...

The present research was carried out at Experimental Farm, Department of Agriculture, Mata Gujri College, Fatehgarh Sahib, Punjab during winter season 2020-21. experiment laid in randomized block design with seven treatments (Control, 20gy, 40gy, 60gy, 80gy, 100gy and 120gy) the were replicated thrice. From it can be concluded that lower dose (20gy) gamma irradiation show positive result on gro...

In addition to its renowned poisonous effects, carbon monoxide (CO) is being recognized for its beneficial actions on inflammatory and vasoregulatory pathways, particularly when applied at low concentrations via CO-releasing molecules (CO-RMs). In the lung, CO gas and CO-RMs are suggested to decrease pulmonary vascular tone and hypoxic pulmonary vasoconstriction (HPV). However, the direct effec...

This article describes in extended detail the methodology applied for acquisition of transcriptomic data, and subsequent statistical data modelling, published by Wilson et al. (2015) in a study of the effects of carbon monoxide-releasing molecule-3 (CORM-3 [Ru(CO)3Cl(glycinate)]) on heme-deficient bacteria. The objective was to identify non-heme targets of CORM action. Carbon monoxide (CO) inte...

Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-induced apoptosis in the mouse intestinal epithelial cell line, MODE-K. In the ...

BACKGROUND Carbon monoxide (CO) synthesized by heme oxygenase 1 (HO-1) exerts antinociceptive effects during inflammation but its role during neuropathic pain remains unknown. Our objective is to investigate the exact contribution of CO derived from HO-1 in the modulation of neuropathic pain and the mechanisms implicated. METHODOLOGY/PRINCIPAL FINDINGS We evaluated the antiallodynic and antih...