Acute toxicity of copper sulphate (CuSO4.5H2O) to tilapia (Oreochromis niloticus) and catfish (Clarias gariepinus) species was investigated using toxicity index of 96 hours LC50 and the quantal response determined by the statistical probit analysis method. In response to the lethality of the copper toxicant, behavioral anomalies (locomotor response) of the exposed fish species were studied as i...

Bacterial contamination of touch surfaces poses a serious threat for public health. The use of bactericidal surface materials, such as copper and its alloys, might constitute a way to aid the use of antibiotics and disinfectants, thus minimizing the risk of emergence and spread of multiresistant germs. The survival of Escherichia coli on metallic copper surfaces has been studied previously; how...

The copper-catalyzed 1,3-dipolar cycloaddition of an azide to a terminal alkyne (CuAAC) is one of the most popular chemical transformations, with applications ranging from material to life sciences. However, despite many mechanistic studies, direct observation of key components of the catalytic cycle is still missing. Initially, mononuclear species were thought to be the active catalysts, but l...

Copper appears to be influencing the distribution and abundance of phytoplankton in marine environments, and cyanobacteria are thought to be the most sensitive of the phytoplankton groups to copper toxicity. By using growth assays of phylogenetically divergent clades, we found that coastal strains of marine Synechococcus species were more tolerant to copper shock than open-ocean strains. The gl...

Here we report on the analysis of two aquatic plant species, Azolla caroliniana and Lemna minor, with respect to tolerance and uptake of co-occurring arsenic, copper, and silicon for use in engineered wetlands. Plants were cultured in nutrient solution that was amended with arsenic (0 or 20 microM), copper (2 or 78 microM), and silicon (0 or 1.8 mM) either singly or in combination. We hypothesi...

The Burkholderia cepacia complex (Bcc) consists of 17 closely related multidrug resistant bacterial species that are difficult to eradicate. Copper has recently gained attention as an antimicrobial agent because of its inhibitory effects on bacteria, yeast, and viruses. The objective of this study was to evaluate the antibacterial activity of copper surfaces and copper powder against members of...

background: this study aims to investigate the patterns of bioaccumulation and depuration of copper in the selected kidney and liver of capoeta fusca. methods: the fish were collected between september and november 2010 from a qanat in birjand. they were exposed to two types treatments with copper (0.25 and 0.75 mg/l) for a period of 41 days. the fish under study were exposed to the above-menti...

Copper-dependent lytic polysaccharide monooxygenases (LPMOs) are enzymes that oxidatively deconstruct polysaccharides. The active site copper in LPMOs is coordinated by a histidine-brace. This utilizes the amino group and side chain of the N-terminal His residue with the side chain of a second His residue to create a T-shaped arrangement of nitrogen ligands. We report a structural, kinetic, and...

In vivo, copper(II) is a major source of reactive oxygen species (ROS) via Fenton Haber Weiss reactions. Interest in Alzheimer’s disease has led to intensive studies into the generation of ROS catalyzed by copper(II) with or without the presence of β-amyloid (Aβ) peptides and biological antioxidants. We establish a potential connection between tyrosine nitration and copper(II) toxicity in neuro...