Background: The memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (STZ) in rats through activation of oxidative stress, is accepted as sporadic Alzheimer’s disease (AD) model in most experimental studies. Dimethyl sulfoxide (DMSO) as a solvent is widely used in animal studies to have antioxidant effects as well. However, no report is available ab...

previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. both ascorbic acid and dopamine receptor have an important role in learning and memory processes. however, the central interaction between ascorbic acid and dopamine d2 receptor on spatial learning and memory has not yet been elucidated. all experiments were carried out on mal...

Effect of administration of Rice bran oil (RBO) was evaluated on haloperidol elicited tardive dyskinesia in rats. Albino Wistar rats treated with haloperidol in drinking water at a dose of 0.2mg/kg/day and RBO by oral tubes at a dose of 0.4 mL/day for 5 weeks. Motor coordination, VCMs and 8-hydroxy-2-(di-n-propylamino) tetraline)[8-OH-DPAT] _syndrome were monitored. Striatal serotonin (5-hydrox...

AIMS (1) To examine the relation between neurological soft signs and measures of cognition, coordination, and behaviour in mainstream schoolchildren. (2) To determine whether high soft sign scores may predict children with significant problems in other areas. METHODS A total of 169 children aged between 8 and 13 years from mainstream schools were assessed. They form part of a larger study int...

Narrative ability is one of the most promising ways to assess communicative competence in children: Coordination of lexical, morphosyntactic, phonological, and pragmatic elements is needed to produce narrations. Narratives might even serve as a diagnostic tool for Specific Language Impairment, since children with Specific Language Impairment are reported to have difficulties producing (oral) na...