Carey Franklin Coombs achieved great distinction as a physician and pioneer of cardiac research despite a relatively early death at the age of 52 years. At Bristol General Hospital he organised a University Centre of Cardiac Research where he pursued his studies of rheumatic heart disease, cardiovascular syphilis and the aetiology of other cardiac diseases, Lawrence O'Shaughnessy gave the first...

Even though clinical features in autoimmune haemolytic anaemia vary according to the type of AIHA, anaemic syndrome stays common for most cases. A positive Coombs test or direct anti-globulin developed 1945 by Coombs, Mourant and Race, is deciding factor AIHA diagnosis. Since immunologic mechanisms causing erythrocyte destruction between AIHAs, treatment also different. Empirical approach with ...

THORNLEY, Wilson, Hormaeche, Oates and Coombs (1979) used a method of solid-phase radioimmunoassay (RIA) devised for brucella antigens (Wilson, Thornley and Coombs, 1977) to detect gonococcal antigens in a buffer system. When this test was used to detect gonococcal antigens in urine samples, many were found to be strongly inhibitory. This paper describes a study of some of the properties of the...

Chronic hepatosplenic suppurative brucellosis (CHSB) is a local reactivation of a previous brucellosis, coursing with an immunoglobulin G (IgG) and IgA secondary immunological response. The observation of two cases of CHSB with an apparent IgM response gave rise to a detailed serological study of three of our patients. We studied the first sample from all three patients and successive samples f...

The purpose of this article is three-fold: to demonstrate the interface between the theory of scaling and graph theory, to determine the class of unidimensional graphs, and to provide a method for analyzing data which consists cf both dominance and indifference relations. The most definitive work on the subject of data analysis is Coombs’ (1976) A Theory of Data in which eight types of data are...

OBJECTIVE To evaluate signs of haemolysis in babies of Rh-D negative mothers who underwent prophylaxis with anti-D immunoglobulin during pregnancy. DESIGN The following were evaluated in all babies of Rh-D negative mothers born within a three month period in our department: haemoglobin level, packed cell volume, mean corpuscular volume, reticulocytes, bilirubin level, and direct Coombs' test ...

Erythrocytes obtained from patients who manifest autoimmune hemolytic anemia can be divided into at least three categories by the nature of their protein coats as determined by direct antiglobulin (Coombs) test: IgG alone, IgG and complement (C), C alone. IgG antibodies were detected by direct Coombs Test at 4#{176}Cbut not at 37#{176}Cin patients of type 3 A.H.A. Experiments at 4, 10, 15, 20, ...

Tuberculosis (TB), a common health problem in developing countries, is a specific multi-systemic infection that can lead protean manifestations in any organ system. Anemia and leukocytosis are the most frequent hematological findings at presentation and during the long clinical course of the disease. Coombs’-positive hemolytic anemia and immune thrombocytopenic purpura (ITP) are exceedingly rar...

The presence of antibodies was determined in the serum and cerebrospinal fluid in six patients with neurobrucellosis using the Rose Bengal test, the microdilution agglutination test, and the Coombs' test. Four of the patients were followed up for more than three months. The Rose Bengal test and the microagglutination test were positive in cerebrospinal fluid in five of the six cases at some sta...