Background:Epilepsy is accompanied by neurodegenerative changes, particularly those in the retina. Elucidation of mechanisms retinal alterations a model epileptic syndrome may allow for development new approaches to pharmacological vision correction. Purpose: To assess morphological characteristics retina, treated with niacin oxy-ethylidene phosphonate germinate (MIGU-4), pentylenetetrazole (PT...

Neuron restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor, has been reported to modulate neuronal excitability and acts as endogenous anticonvulsant in kainic acid-induced or kindling-evoked seizure activity. However, whether NRSF functions in pentylenetetrazol (PTZ)-induced seizure activity has never been studied. To investigate the role of end...

Background and Objective: Regarding the prevalence of epilepsy in human society and with respect to insufficiency of usual treatments, new strategies and methods for medical treatment of epileptic patients are necessary. As NMDA receptor antagonists are the most prominent anti-epileptic drugs, in the present study, we synthesized and investigated anti-epileptic effect of a new piperidine deriva...

The aims of the present work were to investigate the effects of the repeated administration of Parawixin2 (2-amino-5-ureidopentanamide; formerly FrPbAII), a novel GABA and glycine uptake inhibitor, in rats submitted to PTZ-induced kindling. Wistar rats were randomly divided in groups (n=6-8) for different treatments. Systemic injections of PTZ were administered every 48 h in the dose of 33 mg/k...

Objective: To investigate the electroencephalogram (EEG) characteristics, cerebral blood fl ow, glucose metabolism, and pathological characteristics in cats kindled by pentylenetetrazol (PTZ). Methods: Ten adult male cats received intramuscular injections of PTZ at a sub-convulsive dose of 25 mg/kg once daily. Cats were considered to be kindled when a class V or above seizure was observed. Subs...

background and objectives: most antiepileptic drugs that are commonly being used in the clinic have a wide range of unwanted side effects; while some species of pistachioshave been used in the traditional medicine to treat epilepsy. the aim of the present study was to investigate the anticonvulsant effects of the hydroalcoholic extract of pistacia vera l. in pentylenetetrazole (ptz)-induced che...

Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/Kg) every 48 h. Once kindled, some of the animals received a single injection of cysteamine (200 mg/Kg). Somatostatin-like immunoreactivity (SLI) and 125 I-Tyr11-somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling th...

lead is known to be a potent neurotoxin that can cause seizure activity in humans and animals. also, epileptic type convulsion is a known complication of hypothyroidism. this study was performed to determine the effect of propylthiouracil (ptu)-induced hypothyroidism and chronic lead exposure on pentylenetetrazol (ptz)-induced kindling parameters. the test was carried out by using male albino r...

introduction: considering the prevalence of epilepsy and the failure of available treatments for many epileptic patients, finding more effective drugs in the treatment of epilepsy seems necessary. oxidative stress has a special role in the pathogenesis of epileptic syndrome. therefore, in the present study, we have examined the anti-epileptic and anti-oxidant properties of the ferula assa foeti...