We report an efficient, atom economical general acid-base catalyzed one-step multi-gram synthesis of azepinomycin from commercially available compounds in water. We propose that the described pH-dependent Amadori rearrangement, which couples an amino-imidazole and simple sugar, is of importance as a potential step toward predisposed purine nucleotide synthesis at the origins of life.

Introduction Tracheostomy (TCT) places an high social and economical burden not only for patients and their families, but also for institutions and the management of their beds. Longitudinal studies are contradictory, due to different non-standard practices, different circuits of these patients in the hospitals and the differentiation of human resources. Therefore, the creation of decannulation...

Entanglement lies in the heart of almost all methods of quantum communication and computation. Efficient and economical generation of entangled states of light are of crucial importance for the success of future quantum communication applications. This article introduces the experimental methods to produce entangled light modes both in the discrete and continuous variable regime.

The electric system needs to balance supply and demand on a moment to moment basis. Energy commodities such as coal, oil and natural gas can be readily stored in massive quantities. However, the storage of electricity has been relatively complex and expensive. Today, with the changing ways in which electricity is generated and used, increased penetration of renewable energy sources and smart gr...

economists look at the entrepreneurship from the prospective of profitability, investment, risk, and insight supporting the economical development but it seems that, in modern societies, entrepreneurship`s function is beyond the economical bounds. according to the stage and importance of entrepreneurship which is known as the society’s economic and culture evolution engine, it is necessary to d...

Goal: After completing this continuing education article the reader will be able to: understand the importance of ensuring appropriate leadership support and operational infrastructure are dedicated to the improvement of safe medication use, describe the importance of proper alignment between medication safety principles and front-line practice, and develop an initial plan for improving medicat...