consanguineous marriage is a common custom in iran, and different statistical figures in this regard have been reported from various regions of the country. therefore, it seems necessary to examine the viewpoints of medical genetics, the quran and the infallibles about this issue. consanguineous marriage is one of the most important causes of congenital anomalies. the numerous advices and solut...

Consanguinity or inter-cousin marriage is a phenomenon quite prevalent in certain regions around the globe. Consanguineous parents have a higher risk of having offspring with congenital disorders. It is difficult to model large scale consanguineous parental populations because of disparate cultural issues unique to regions and cultures across the globe. Although consanguinity has previously bee...

BACKGROUND Consanguinity or marriage between close blood relatives, in particular first cousins is widely practised and even socially encouraged in many countries. However, in the face of fertility transition where the number of cousins eligible to marry declines, how might such constraints on consanguinity develop in the future? OBJECTIVE Numerous studies have stated that the practice cannot c...

The north-western populations of Pakistan in the Federally Administered Tribal Areas (FATA) adjoining the Pakistan-Afghanistan border are an amalgamation of native and migrated Pashtun tribes. These tribal populations are in transition due to war conditions and geo-political turmoil on both sides of the border since the Soviet invasion in 1979. Bio-demographic and epidemiological data for these...

Mal de Meleda is a rare transgressive palmoplantar keratoderma with an estimated prevalence of 1 in 100,000 individuals. It was first described in 1826 by Stulli on the island of Mljet. Its autosomal recessive inheritance was described in 1938, and the defective gene was localized to chromosome 8 qter in 1998. Clinical features are the result of abnormal palmoplantar keratinization and include ...

Children of consanguineous unions carry long runs homozygosity (ROH) in their genomes, due to parents' recent shared ancestry. This increases the burden recessive disease populations with high levels consanguinity and has been heavily studied some groups. However, there little investigation broader effect on patterns genetic variation a global scale. study, which collected published data inform...

Background: Vascular malformation is extremely rare, yet has a profound impact on quality of life, aesthetic and functional disorders. Aim: To show that endogamy and consanguinity may represent risk factors for labial venous malformation (LVM) development. Materials and Methodology: Among the 18093 scrutinized families on a 20 years back period from marriage registers, five families with a chil...