Consanguineous marriages have been common throughout human history, and remain so even today in many parts of the world. Many Arab countries display some highest rates consanguinity and, specifically, first cousin which may encompass 25 to 30 percent all marriages. The effects inbreeding on reproductive outcome extensively studied. It used be generally believed that contributed increased mortal...

A natural numerical measure of consanguinity is developed that applies to individuals with arbitrary multiple kinship connections. For simple relationships the consanguineal distance specializes to the civil degree, less two if the relationship goes through full siblings. This measure is deduced from axioms motivated by an heuristic picture of blood mixtures. The formula suggests a quantum mech...

Primary immunodeficiencies (PIDs) are a heterogeneous group of genetic disorders caused by defects in the immune system that predispose patients to infections, autoimmune diseases, lymphoproliferation and malignancies. Most PIDs are inherited in an autosomal recessive pattern; therefore, they are more common in areas with high rates of consanguineous marriage. Reports about PIDs from these area...