AIM To assess the association among social status, prevalence of consanguineous marriages, and the effects of consanguinity on reproductive behavior and mortality in Tunisia. METHODS The study included data on a total of 1741 live-births born from November 1989 to October 1990 in the maternity ward of the University-Hospital Fattouma Bourguiba of Monastir, Tunisia. After delivery, women fille...

Reciprocal translocations represent one of the most common structural rearrangements observed in humans. Estimates of the population frequency range from 1/673 to 1/1000. We have described two novel balanced translocations in two unrelated families who experienced Recurrent spontaneous abortions (RSA) following their separate non-consanguineous marriages. Initial cytogenetic studies were perfor...

AIMS To identify the proportion of familial cases of isolated ocular colobomatous malformations in a case series from south India. METHODS Children with ocular coloboma without systemic features were recruited from multiple sources in Andhra Pradesh, India. Their families were traced, pedigrees drawn, and family members examined. RESULTS 56 probands, 25 females (44.6%) and 31 males (57.4%) ...

Consanguineous marriages have a high prevalence among Muslim-majority countries, and the ratio is increasing in Saudi population [1]. Nowadays, more than half of all the marriages in Saudi Arabia are marriages between cousins [2]. Different types of consanguineous marriages exist, such as marriage between first cousins, which is the most common one, marriage between second cousins, and marriage...

Marriage between biological relatives is widely popular in many parts of the world, with over 1000 million people living in countries where 20-50+% of unions are contracted between couples related as second cousins or closer. Consanguinity is, however, a controversial topic, in part due to public misunderstanding, complicated by often exaggerated past estimates of the adverse health outcomes. W...

Aims: To identify the proportion of familial cases of isolated ocular colobomatous malformations in a case series from south India. Methods: Children with ocular coloboma without systemic features were recruited from multiple sources in Andhra Pradesh, India. Their families were traced, pedigrees drawn, and family members examined. Results: 56 probands, 25 females (44.6%) and 31 males (57.4%) w...

Meckel Gruber syndrome is an uncommon, lethal, autosomal recessive disorder, associated consistently with polycystic kidneys, posterior encephalocoele and polydactly. We report three cases in non-consanguineous marriages, suggesting that the single gene defect occurs more commonly in non-consanguineous marriages than mutant genes associated with other autosomal recessive disorders that are usua...