Aims and Objectives: The objective of the present study is to assess the genetic composition of the two subgroups of Salis and the extent of genetic differentiation among them with the help of various demographic and genetic variables. Materials and Methods: A total of 520 couples belonging to two sub-groups namely, Padmasalis and Pattusalis residing in and around Visakhapatnam and Vizianagaram...

We studied 187 patients attending special educational institutions in Saudi Arabia who were blind before the age of 14. All patients underwent complete ophthalmological evaluation. The visual acuity in 31% of the patients was no light perception and in 58% light perception to counting fingers at 3 feet (1 m). 70% were blind before age 2. Prior to 1962 acquired diseases led to blindness in 75% o...

Studies of animal populations suggest that low genetic heterozygosity is an important risk factor for infection by a diverse range of pathogens, but relatively little research has looked to see whether similar patterns exist in humans. We have used microsatellite genome screen data for tuberculosis (TB), hepatitis and leprosy to test the hypothesis that inbreeding depression increases risk of i...

Consanguinity ("blood relation", from the Latin consanguinitas ) is the property of being from the same kinship as another person. In that aspect, consanguinity is the quality of being descended from the same ancestor as another person. Consanguineous marriage is frequent in many populations. In fact, it has been recently estimated that consanguineous couples and their progeny suppose about 10....

INTRODUCTION Mental retardation (MR) has heterogeneous aetiology mostly with genetic causes. Chromosomal aberrations are one of the most common causes of MR. Reports on chromosome abnormality rate among consanguineous families are sparse. In order to identify the chromosome abnormality rate in idiopathic mental retardation from consanguineous marriages, a total of 322 Iranian families with posi...

Most of the inborn errors of metabolism (IEM) are autosomal recessively inherited and they are more frequent in the countries where consanguineous marriages are commonly practiced. Rarely, more than one IEM are seen in the siblings of one family or in the same sibling. Here we report a patient with both argininosuccinic aciduria (ASA) and methylmalonic acidemia (MMA) and our therapeutic approac...

To determine the prevalence of consanguineous marriages and estimate the effects of consanguinity on reproductive behaviour and mortality, household and hospital-based surveys were conducted in 11 cities in the Pakistan province of Punjab between 1979 and 1985. The 9520 women interviewed reported 44,474 pregnancies, with data collected on maternal and paternal ages at marriage, abortions/miscar...

Consanguineous marriages and their effects on human beings in light of biological effects of genetic sicknesses are discussed in many studies. Among many, the likelihood of sicknesses such as phenylketonuria, thalassemia, Landsteiner–Fanconi–Anderson’s syndrome, hemophilia and many neuro system anomalies increase drastically in countries with consanguineous marriage practices resulting in incre...

Background: Physicians and geneticists face challenges in making accurate diagnoses during clinical evaluations; affecting patients clinicians. The aim of this study was to estimate the hit rate non-consanguineous population. Moreover, prevalence genetic disorder both consanguineous non- population Saudi Arabia at King Abdulaziz Medical City Riyadh data. Methods: We reviewed 681 families 1563 i...