نتایج جستجو برای: connexin 43
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Abstract Activation and proliferation of antigen specific T cells depends on the interaction multiple signaling molecules with TCR/CD3 complex. We report that expression connexin 43 (Cx43), a gap junction protein, is critical for expansion antigen-specific or self-reactive effector CD4 +T cells. While mediated intercellular communication has been main focus research, cytoplasmic C-terminus Cx43...
Reduced expressions of plakoglobin and connexin 43 have been reported in the myocardium of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, the relationships between these expression abnormalities and the clinical features of ARVC remain unknown.The expressions of plakoglobin and connexin 43 in myocardial biopsy specimens from 10 patients with confirmed ARVC, and 1...
Gap junctions consisting of connexin 43 subunits provide intercellular communication between astrocytes, contributing to their function of maintaining the central nervous system (CNS) microenvironment. Magnetic resonance imaging (MRI) studies demonstrate prolonged astrocyte swelling related to seizures, while in vitro studies show the disruption of intercellular coupling and the cytotoxic swell...
Multiple gap junction proteins (connexins) and channels have been identified in developing and adult heart. Functional expression of the three connexins found in chick heart (connexin42, connexin43, and connexin45) by stable transfection of communication-deficient neuro2A (N2A) cells revealed that all three connexin cDNAs are capable of forming physiologically distinct gap junctions that differ...
BACKGROUND Clinically, it is well known that injury of mandibular nerve fiber induces persistent ectopic pain which can spread to a wide area of the orofacial region innervated by the uninjured trigeminal nerve branches. However, the exact mechanism of such persistent ectopic orofacial pain is not still known. The present study was undertaken to determine the role of connexin 43 in the trigemin...
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