نتایج جستجو برای: conjugates gradient method

تعداد نتایج: 1733637  

2014
Dipali Ruhela Saul Kivimäe Francis C. Szoka

Herein, we describe an efficient and high-yielding method to synthesize hyaluronan oligosaccharide-lipid conjugates. This strategy is based on first covalently attaching diphytanoyl glycerophosphatidylethanolamine (DiPhPE) to commercially available high molecular weight hyaluronic acid (HA), via the carboxylate group of the glucuronic acid using carbodiimide chemistry. The HA-lipid conjugate mi...

Journal: :Journal of immunological methods 1988
A Jeanson J M Cloes M Bouchet B Rentier

Four monoclonal antibodies belonging to different subclasses and with differing isoelectric points were coupled to horseradish peroxidase (HRP) and alkaline phosphatase (AP) using various conjugation procedures. The conjugates were tested by enzyme immunoassay and their efficiency was characterized by the antibody and enzyme concentrations needed to obtain an arbitrary OD value. The suitability...

2018
Arianna Filntisi Dimitrios Vlachakis George K. Matsopoulos

Antibody-drug conjugates (ADCs) have emerged as a promising class of targeted anticancer therapy, and it is distinguished from traditional chemotherapeutic ap‐ proaches by its potential to kill cancer cells with limited side effects. Site-specific conjugation is one of the current challenges in ADC development because it allows for controlled conjugation and production of homogeneous ADCs. This...

Journal: :Cancer research 1987
K P Borlinghaus D A Fitzpatrick N D Heindel J A Mattis B A Mease K J Schray D J Shealy H L Walton D V Woo

Misonidazole was covalently conjugated (3-68 mol drug/mol antibody) to 19-9 monoclonal antibody directed against a colorectal carcinoma tumor-associated antigen as a method for targeting radiosensitizing agents. This attachment was accomplished by the mixed anhydride method using the hemisuccinate derivative of misonidazole. Evaluation of conjugates in vitro shows a loss of antibody binding act...

Journal: :Clinical chemistry 1971
G S Pinkus J L Pinkus

Ammonium sulfate precipitation of urinary 17-ketosteroid conjugates is a rapid, effective method for isolating and purifying them. Negligible quantities of pigment are produced during acid hydrolysis of solutions of the precipitated conjugates. Despite elimination of nonspecific chromogenic material, colorimetric determinations of Zimmerman chromogens with use of the Allen correction of absorba...

Journal: :The Journal of biological chemistry 1960
M LEVITZ G P CONDON W L MONEY J DANCIS

In a recent report from these laboratories (2), an in situ perfusion method was described which could be used to measure the transfer of substances in either direction across the guinea pig placenta. When the procedure was applied to the estrogens, it was found that the unconjugated hormones, estrone, estradiol170, and estriol were transferred quickly under conditions in which the placenta pose...

Journal: :J. Applied Mathematics 2012
Jin-kui Liu Xianglin Du Kairong Wang

In this paper the conjugate gradient (CG) method is employed for identifying the parameters of crack in a functionally graded beam from natural frequency measurement. The crack is modeled as a massless rotational spring with sectional flexibility. By using the Euler-Bernoulli beam theory on two separate beams respectively and applying the compatibility requirements of the crack, the characteris...

Journal: :bulletin of the iranian mathematical society 2011
n. mahdavi-amiri r. yousefpour

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