Most cases of neonatal sepsis and meningitis caused by group B streptococci (GBS) are attributable to one of four major capsular serotypes: Ia, Ib, II, or III. Because resistance to infection with GBS has been correlated with the presence of serum antibodies to the type-specific capsular polysaccharides in both experimental animals and human neonates, efforts have been made to elicit protective...

BACKGROUND Protection against Haemophilus influenzae type b (Hib), a rapidly invading encapsulated bacteria, is dependent on maintenance of an adequate level of serum antibody through early childhood. In many countries, Hib vaccine booster doses have been implemented after infant immunization to sustain immunity. We investigated the long-term persistence of antibody and immunological memory in ...

There is still a lack of effective vaccination strategies for patients with a deficient antibody response to bacterial polysaccharide antigens. In an open trial, we evaluated the immunogenicity and tolerance of a new 7-valent pneumococcal conjugate vaccine in 22 infection-prone nonresponders to pneumococcal polysaccharide vaccine and 21 controls. In the patient group, nonresponsiveness was conf...

CONTEXT Pneumococcal conjugate bacterial vaccines that are able to prevent invasive disease and mucosal infections have been developed. OBJECTIVE A meta-analysis of published data from trials on pneumococcal conjugate vaccine was performed to determine the efficacy in reducing the incidence of invasive disease caused by Streptococcus pneumoniae, pneumonia, and acute otitis media in healthy in...

Children with sickle cell disease were immunized with either 2 doses of 7-valent pneumococcal conjugate vaccine followed by 1 dose of 23-valent pneumococcal polysaccharide vaccine or a single dose of 23-valent vaccine. Functional antibodies to 7 vaccine serotypes were measured by a flow cytometric opsonophagocytic assay (OPA) and compared with IgG anticapsular polysaccharide antibody concentrat...

The number of notified cases of invasive pneumococcal disease (IPD) in the 1st quarter of 2016 was substantially fewer than the previous quarter and marginally less than the number of notified cases in the 1st quarter of 2015. Overall, the decline in disease due to the serotypes targeted by the 13-valent pneumococcal conjugate vaccine (13vPCV) has been maintained across all age groups since the...

447 VOLUME 47__MAY 17, 2010 I refer to the article “Vi conjugate Typhoid Vaccine” written by Garg SP(1) on behalf of the manufacturer of Peda TyphTM in response to my previous article on the same subject(2). The author states that “this novel vaccine has been found to be safe and effective in inducing very high levels of immune response (>90%) in infants, young children and adults”, and goes fu...

The number of notified cases of invasive pneumococcal disease (IPD) in the 2nd quarter of 2016 was substantially more than the previous quarter and marginally more than the number of notified cases in the 2nd quarter of 2015. Overall, the decline in disease due to the serotypes targeted by the 13-valent pneumococcal conjugate vaccine (13vPCV) has been maintained across all age groups, since the...

background and objectives: treatment of pseudomonas aeruginosa infections is greatly hampered by innate and acquired antibiotic resistance. the goal of this study was to compure the immunogenicity of conjugates of p. aeruginosa depolymerized alginate-diphtheria toxoid (d-algdt) and p. aeruginosa detoxified lipopolysaccharidediphtheria toxoid (d-lpsdt) in mouse model. materials and methods: algi...