Synthetic retinoids have generated in the fields of dermatology and oncology due to their potent anti-proliferative and differentiation activities. We efficiently synthesized different demethyl geranylgeranoic acid (GGA) analogs, and evaluated their biological activities. Among the demethyl analogs synthesized, 3-demethyl derivative exhibited the highest anti-proliferative activity in HL-60 cel...

Ginsenosides separated by silica gel TLC blotted to a polyvinylidene difluoride (PVDF) membrane was treated with a NaIO4 solution followed by bovine serum albumin (BSA), resulting in a ginsenoside-BSA conjugate on a PVDF membrane. The blotted bands were stained with anti-ginsenoside Rg1 and Rb1 monoclonal antibodies (MAbs). The newly established double staining with the Western blotting methods...

BACKGROUND AND AIM: In public health, health literacy (HL) is rather a new conception. In this regard, oral health as a critical public health issue that affects women’s health. The objective of the present study was to determine oral health self-care behavior and its relationship with HL.METHODS: This cross-sectional study was performed on 232 women who referred to health centers of Tabriz, Ir...

Hodgkin lymphoma (HL) accounts for about 10% of all childhood cancers. Five-year survival rates with modern therapies are now approaching >90-95% as a consequence of its significant sensitivity to both chemotherapy and radiation. The current challenge is to determine how much therapy is needed to improve survival and how to adapt treatment to the patient to prevent these long term toxicities. T...

introduction: children learn to communicate by hearing sounds. if there is hearing loss, the cognitive and speaking abilities and language learning will deteriorate. early detection and intervention are important factors in the successful treatment of hearing loss in children. hearing loss (hl) is divided into two main groups: conductive hearing loss (chl) and sensorineural hearing loss (snhl),...

Abstract This study aims to synthesize seismic observations with gravity and magnetic data suggest a new scenario on the development of Harrat Lunayyir (HL) tectonic system eastern Red Sea coastline, Saudi Arabia. Gravity aeromagnetic anomalies distinctly mapped NE NW trends, while InSAR depict small NW–SE graben an dyke. High-resolution relocations, which are well-consistent focal mechanism so...

Introduction: Children learn to communicate by hearing sounds. If there is hearing loss, the cognitive and speaking abilities and language learning will deteriorate. Early detection and intervention are important factors in the successful treatment of hearing loss in children. Hearing loss (HL) is divided into two main groups: conductive hearing loss (CHL) and sensorineural hearing loss (SNHL)...

We have previously made a Mr 195,000 immunotoxin (IT) composed of mAb C242 coupled to Pseudomonas exotoxin A. This IT inhibited growth but did not cause regression of a human colorectal cancer xenograft growing in nude mice (W. Debinski et al., J. Clin. Invest., 90: 405-411, 1992). Since smaller proteins penetrate into tissues and tumors better than larger proteins, we have made a smaller recom...

BACKGROUND Brentuximab vedotin is a CD30-directed antibody-drug conjugate. Retreatment with brentuximab vedotin monotherapy was investigated in patients with CD30-positive Hodgkin lymphoma (HL) or systemic anaplastic large cell lymphoma (ALCL) who relapsed after achieving complete or partial remission (CR or PR) with initial brentuximab vedotin therapy in a previous study (ClinicalTrials.gov NC...

Oxime extractants 3-tert-butyl-2-hydroxy-5-methyl benzaldehyde oxime (HL1) and 3-tert-butyl-2-hydroxy-5-methoxy benzaldehyde oxime (HL2) were synthesized and characterized by conventional spectroscopic methods. Suitable lipophilic nature of the prepared extractants allowed examining the ability of these molecules for extr...