BACKGROUND To determine the relationships of potential occupational exposure to antineoplastic drugs with cancer incidence and adverse pregnancy outcomes in a historical prospective cohort study of female registered nurses (RNs) from British Columbia, Canada (BC). METHODS Female RNs registered with a professional regulatory body for at least one year between 1974 and 2000 formed the cohort (n...

Bone marrow and peripheral blood cells from three newborns with Down's syndrome and transient myeloproliferative disorders were cultured in vitro. In the methylcellulose semiliquid system, normal colony formation with maturation and differentiation into granulocytes and monocyte-macrophages were observed in all three patients. This is different from the growth pattern usually seen in acute nonl...

Imatinib, a tyrosine kinase inhibitor has revolutionized the therapy of Philadelphia chromosome positive chronic myeloid leukemia. Side effects of imatinib include grade 1-4 hepatotoxicity in a subset of patients. We report the case of a 46-year-old male with chronic myeloid leukemia, who developed hepatic hemosiderosis during treatment with imatinib. After ruling out the established congenital...

A 4-yr-old boy was studied who placed to the left of the curve from showed typical findings of juvenile normal adult blood; the hemoglobin chronic myelogenous leukemia, inA2 level and the erythrocyte I antigen cluding massive hepatosplenomegaly, titer were reduced; and a structural thrombocytopenia, low leukocyte alkaanalysis of the ‘i-chain of the fetal line phosphatase, and absence of a hemog...

We report a nine year old male with Philadelphia positive Precursor B Acute Lymphoblastic Leukemia who was diagnosed with mediastinal actinomycosis following failed central line placement. The patient had a normal chest X-Ray at diagnosis, had a good response to initial chemotherapy, but subsequently developed a widened mediastinum with vascular compression. The differential diagnosis for this ...

We presents an infant with several indurated plaques and nodules scattered on her body. She was brought to the hospital because of fever, runny nose and cough from one month ago. During the examination and investigation the plaques and nodules grabbed the attention of the clinicians and the skin biopsy and other lab works revealed the diagnosis of congenital leukemia.

Objective: Fanconi’s anemia (FA) is an autosomal recessive disorder characterized by a progressive pancytopenia,variable congenital abnormalities and an increased risk for the development of acute myeloid leukemia (AML). The objective of this study is to evaluate AML in the patients with FA diagnosed and followed-up in the Department of Pediatric Hematology at Ankara University School of Medici...