University-Industry Collaboration (UIC) creates highly skilled and productive business graduates for meeting demand of industry, globalization, knowledge economy, and job market at home and abroad. In coping with ongoing acute competitive pressures of the information edge, higher education curricula of business needs to be intellectually planned, through collaboration between university and ind...

In this study, we presented a mathematical model for analyzing the heat source/sink effect on magnetohydrodynamic two-dimensional ferrofluid flow past a cone and a vertical plate in the presence of volume fraction of ferrous nanoparticles. The governing partial differential equations are transformed as ordinary differential equations making use of similarity solutions and solved numerically wit...

Retinal cone photoreceptors mediate fine visual acuity, daylight vision, and color vision. Congenital hereditary conditions in which there is a lack of cone function in humans cause achromatopsia, an autosomal recessive trait, characterized by low vision, photophobia, and lack of color discrimination. Herein we report the identification of mutations in the PDE6C gene encoding the catalytic subu...

PURPOSE To assess changes in rod and cone visual functions in a mouse model of Fundus albipunctatus with disrupted 11-cis-retinol dehydrogenase (RDH) genes after pharmacologic treatment with an artificial retinal chromophore. METHODS Retinoid levels and photoreceptor functions of Rdh5-/-Rdh11-/- mice at a variety of light intensities were analyzed with normal-phase HPLC and ERG techniques. Pr...

The Palaeogene Ardnamurchan central igneous complex, NW Scotland, was a defining place for the development of the classic concepts of cone-sheet and ring-dyke emplacement and has thus fundamentally influenced our thinking on subvolcanic structures. We have used the available structural information on Ardnamurchan to project the underlying three-dimensional (3D) cone-sheet structure. Here we sho...

The dark-adapted cone electroretinogram (ERG) is difficult to isolate because of unwanted rod intrusion. We compare dark-adapted cone estimates derived using three techniques. The first uses the cone response on a moderate rod saturating background to estimate the dark-adapted cone response. The second uses red and blue flashes to tease apart cone and rod responses (red-minus-blue technique, [I...

Chromatic discrimination thresholds were measured with and without surrounds along two cardinal axes of chromaticity space. On one axis the level of short-wavelength-sensitive (SWS)-cone excitation was varied for constant long-wavelength-sensitive (LWS)-cone and medium-wavelength-sensitive (MWS)-cone excitations, and on the other axis there were equal and opposite changes in LWS-cone and MWS-co...

PURPOSE Retinitis pigmentosa (RP) is a blinding disease caused by the degeneration of photoreceptors. To further understand the process of degeneration in RP, the authors have traced activation patterns associated with rod and cone photoreceptor degeneration in a mouse model of RP METHODS: The authors used a double-mutant mouse, Rd-FTL, which contains a natural mutation, rd1, affecting the rod ...

PURPOSE To report a novel mouse model of achromatopsia with a cpfl3 mutation found in the ALS/LtJ strain. METHODS The effects of a cpfl3 mutation were documented using fundus photography, electroretinography (ERG), and histopathology. Genetic analysis was performed using linkage studies and PCR gene identification. RESULTS Homozygous cpfl3 mice had poor cone-mediated responses on ERG at 3 w...

We recently developed a new technique to measure cone inputs to visual neurons and used this technique to seek short-wavelength-sensitive (S) cone inputs to parasol, magnocellular (MC) and midget, parvocellular (PC) ganglion cells. Here, we compare our physiological measurements of S-cone weights to those predicted by a random wiring model that assumes cells' receptive fields receive input from...