Experiments were performed to test the hypothesis that a reduction in the space constant contributes to slow conduction in the infarcted myocardium of dogs 5-8 days after coronary artery occlusion and reperfusion. Standard microelectrode techniques were used to measure action potential characteristics and conduction velocity parallel to fiber orientation in normal and infarcted ventricular epic...

AIMS To use microstructural computer models to study how four features of myocardial architecture affect propagation: brick wall tissue structures, jutting at cell ends, gap junction distribution and conductance along cell borders, and increased structural discontinuity. METHODS AND RESULTS Simulations of longitudinal and transverse plane wave propagation and point propagation were performed ...

Some of the persons involved in an outbreak of ''yusho'' (polychlorinated biphenyl poisoning due to contaminated cooking oil) in Japan during the summer of 1968 complained of numbness or neuralgic limbs. Therefore, peripheral sensory nerve conduction velocity was measured in 21 such patients, and motor nerve conduction velocity in 19 of these. The motor nerve conduction velocity in the ulnar ne...

AIM The aim of this study was to evaluate the use of fibrin glue on nerve anastomosis, and study conduction velocity obtained by surface electrodes. METHODS In this experimental model we evaluated nerve conduction velocity differences in the preoperative and postoperative periods, for the left facial nerve of 12 rabbits. Then, we evaluated whether there were correlations between conduction ve...

OBJECTIVE Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with remodeling of gap junctions and also, although less well-defined, down-regulation of the fast sodium current. The gap junction remodeling and down-regulation of sodium current have been proposed as contributors to arrhythmogenesis in ARVC by slowing conduction. The objective of the present study was to assess th...

This study explores in detail the functional consequences of subtle retraction and detachment of myelin around the nodes of Ranvier following mild-to-moderate crush or stretch mediated injury. An equivalent electrical circuit model for a series of equally spaced nodes of Ranvier was created incorporating extracellular and axonal resistances, paranodal resistances, nodal capacitances, time varyi...

To investigate the physiological adjustments of textile workers exposed to high temperature environment, 10 workers with years of work experience and 12 students with rarely entering into workshop were chose to a hospital for blood test and nerve conduction velocity measurements. The blood test was to measure potassium content, sodium content, calcium content and bicarbonate content in particip...

Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular tachyarrhythmias. A closely spaced square array of 64 electrodes was used to d...

Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.

Tibial motor nerve conduction velocity was measured in rats, before and two months after the induction of diabetes with streptozotocin. A second group of diabetic animals was also administered 1% dietary myoinositol supplements. An analysis of variance was performed on these data. Myoinositol supplements had no effect whatsoever. The period of diabetes had a statistically significant and quanti...