Human mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unknown mechanisms. To define these pathways, we generated mice with a ventricular-restricted knockout of Nkx2-5, which display no structural defects but have progressive complete heart block, and massive trabecular muscle overgrowth found in some patients with Nkx2-5 mutations. At birth, mutant mice display...

Military personnel are at risk for hearing loss due to noise exposure during deployment (USACHPPM, 2008). Despite mandated use of hearing protection, hearing loss and tinnitus are prevalent due to reluctance to use hearing protection. Bone conduction headsets can offer good speech intelligibility for normal hearing (NH) listeners while allowing the ears to remain open in quiet environments and ...

The comparision of bridgeless isolated cuk converter using proportional integral derivative (PID) and neural controller (NC) is presented in this paper. Due to diode bridge rectifier (DBR) conventional converters suffer from high conduction loss. Bridgeless Cuk converter is used to eliminate the issues. bridgeless isolated (BLI) cuk converter is used to withstand high voltage. Compare to Contin...

Advances in technology have led to the development of several implantable bone conduction devices (BCD) employing bone conduction stimulation for the treatment and rehabilitation of mixed and conductive hearing loss [1]. BCD are alternatives when the benefit of conventional prosthetic equipment is limited or contraindicated [1,2]. BCDs directly stimulate the inner ear by skull vibration [1]. Bo...

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na(+), Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conducti...

Aims Loss-of-function of the cardiac sodium channel NaV1.5 is a common feature of Brugada syndrome. Arrhythmias arise preferentially from the right ventricle (RV) despite equivalent NaV1.5 downregulation in the left ventricle (LV). The reasons for increased RV sensitivity to NaV1.5 loss-of-function mutations remain unclear. Because ventricular electrical activation occurs predominantly in the t...

BACKGROUND Loss-of-function mutations in SCN5A, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and Brugada syndrome, which both exhibit variable phenotypic penetrance of conduction defects. We investigated the mechanisms of this heterogeneity in a mouse model with heterozygous targeted disruption of Scn5a (Scn5a(+/-) mice) and compared our resul...

OBJECTIVE To determine whether chronic suppurative otitis media may cause sensorineural hearing loss. METHODS The files of 121 patients with unilateral chronic suppurative otitis media were reviewed in a retrospective study. Air conduction and bone conduction threshold averages were calculated over the speech frequencies (500 Hz, 1,000 Hz, and 2,000 Hz). Thresholds at 4 kHz were examined sepa...