A Physiologically Based Pharmaco Kinetic (PBPK) model, based on a published description of manganese (Mn) kinetics in adult rats, has been developed to describe Mn uptake and tissue distribution in the pregnant dam and fetus during dietary and inhalation exposures. This extension incorporated key physiological processes controlling Mn pharmacokinetics during pregnancy and fetal development. Aft...

Serum concentrations of manganese-containing superoxide dismutase (Mn-SOD; EC 1.15.1.1), a mitochondrial enzyme present in high concentrations in the heart, were measured successively by enzyme immunoassay in 18 patients with acute myocardial infarction (AMI) and in eight with angina pectoris. Results were compared with creatine kinase (EC 2.7.3.2) isoenzyme MB (CK-MB) concentrations in the sam...

Paddy rice (Oryza sativa) is able to accumulate high concentrations of Mn without showing toxicity; however, the molecular mechanisms underlying Mn uptake are unknown. Here, we report that a member of the Nramp (for the Natural ResistanceAssociated Macrophage Protein) family, Nramp5, is involved in Mn uptake and subsequently the accumulation of high concentrations of Mn in rice. Nramp5 was cons...

the concentrations of some heavy metals in sediment from the sinop coasts of the black sea were measured to monitor metal pollution in 2013. the distribution of the heavy metals in sediments of the black sea shows a variable pattern. the objectives of the present study were to elucidate the distribution heavy metals such as cu, pb, zn, ni, mn, fe, as, cd, cr, hg and co in sediment from sinop co...

Manganese (Mn) toxicity is a major constraint limiting plant growth on acidic soils. Superior Mn tolerance in Stylosanthes spp. has been well documented, but its molecular mechanisms remain largely unknown. In this study, superior Mn tolerance in Stylosanthes guianensis was confirmed, as reflected by a high Mn toxicity threshold. Furthermore, genetic variation of Mn tolerance was evaluated usin...

Due to rapid industrialization and urbanization, environmental pollution has become a significant concern in developing countries; therefore, the main objective of the current study is to determine some of the heavy metal (HM) concentrations in the leaves of dusty miller (Cineraria maritima) and purstane (Mesembryanthemum cordifolium) in different general bus terminal along with the green space...

Paddy rice (Oryza sativa) is able to accumulate high concentrations of Mn without showing toxicity; however, the molecular mechanisms underlying Mn uptake are unknown. Here, we report that a member of the Nramp (for the Natural Resistance-Associated Macrophage Protein) family, Nramp5, is involved in Mn uptake and subsequently the accumulation of high concentrations of Mn in rice. Nramp5 was con...

Iron (Fe) and copper (Cu) metabolism are closely intertwined, and a deficiency of Cu may lead to a secondary Fe deficiency. The impact of a severe Cu deficiency on proteins involved in Fe metabolism in the bovine has not been studied. Therefore, a 493 day study was conducted to determine the effect of a severe long-term Cu deficiency on Fe metabolism in beef cattle. Twenty-one Angus calves were...

bioaccumulation of heavy metals in the skulls of black-striped field mice (apodemusagrarius) was compared for two localities in serbia differing in the level of pollution. eight heavy metals: fe, mn, co, cd, zn, ni, pb and cu, were quantitatively analyzed by atomic absorption spectrophotometry.four of them (mn, cd, fe and ni) showed significantly higher concentrations at the polluted location t...

Soluble manganese(III) [Mn(III)] has been thought to disproportionate to soluble Mn(II) and particulate Mn(IV)O2 in natural waters, although it persists as complexes in laboratory solutions. We report that, in the Black Sea, soluble Mn(III) concentrations were as high as 5 micromolar and constituted up to 100% of the total dissolved Mn pool. Depth profiles indicated that soluble Mn(III) was pro...