OBJECTIVE With emergence and geographically expanding of antimalarial resistance worldwide, molecular markers are essential tool for surveillance of resistant Plasmodium parasites. Recently, single-nucleotide polymorphisms (SNPs) in the PF3D7_1343700 kelch propeller (K13-propeller) domain are shown to be associated with artemisinin (ART) resistance in vivo and in vitro. This study aims to inves...

A novel approach to passive propeller blade pitch variation is investigated. To effect passive pitch changes, the propeller blades are allowed to pivot freely about a radial axis, and aerodynamic pitchingmoments are tailored to give favorablebladepitch angles over awide range of advance ratios.Computationalmodelingof the system indicated that a large expansion of the efficient operating envelop...

While head motion is considered a significant problem in magnetic resonance imaging (MRI), there is no data to quantify its extent, severity, or effect on image quality. PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) MRI offers a novel means of quantifying and compensating for head motion. We performed axial T2-weighted PROPELLER (motion corrected: P-CR...

Propeller cavitation noise in the high frequency regime is broadband and yet audibly rhythmic. The study of these processes are important because the shaft and blade rates, as well as other identifying features of the ship, can in principle be inferred from propeller noise modulation characteristics. Conventional wisdom has been that propeller noise is an amplitude modulation of a wide sense st...

BACKGROUND The propeller flap is defined as (1) being island-shaped, (2) having an axis that includes the perforators, and (3) having the ability to be rotated around an axis. The advantage of the propeller flap is that it is a pedicle flap that can be applied to cover defects located at the distal ends of the extremities. The specific aims of the authors' study were (1) to evaluate the usefuln...

Almost all computational fluid dynamics (CFD) simulations of flow around marine propellers use turbulence models that are only well suited for fully turbulent flows, which in some cases may lead to accuracy degradation in the prediction of propeller performance characteristics. The discrepancy between computed thrust and torque and corresponding experimental data increases with increasing prope...

BACKGROUND AND PURPOSE MR diagnostic of postoperative recurrent cholesteatomas is difficult. Our purpose was to compare multishot fast spin-echo periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) diffusion-weighted MR imaging (DWI) with array spatial sensitivity encoding technique (ASSET) single-shot echo-planar DWI and late postgadolinium T1-weighted MR im...

The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two t...

Speed and position control systems for marine vehicles have been subject to an increased focus with respect to performance and safety. An example is represented by drilling operations performed with semi submersible rigs where the control of position and heading requires high accuracy. Drifting from the well position could cause severe damage to equipment and environment. Also, the use of under...

Speed and position control systems for marine vehicles have been subject to an increased focus with respect to performance and safety. An example is represented by drilling operations performed with semi submersible rigs where the control of position and heading requires high accuracy. Drifting from the well position could cause severe damage to equipment and environment. Also, the use of under...