Introduction We report a case of an eleven years old girl who was referred to our Allergy Outpatient Clinic for the revaluation of a hazelnut allergy. During her infancy she was successfully desensitised to milk and egg. Afterward she had been followed by another Allergy Unit where, according to skin prick test and specific IgE dosage, it had been suggested to strictly avoid peanut and all tree...

Results We studied 143 children (92 M/51 F) aged 2.4 15.6 years. Negative results were found in 20 (14%) with Alternaria, 24 (16.8%) with Alt 1, and 19 with both (13.3%). There was a good correlation between the two determinations (r = 0.935, p <0.001). Overall the levels were higher for Alt a 1 (18.9 ± 24.4) than for Alternaria (15.4 ± 20.1). There were 97 cases (68%) with levels of Alt a 1 > ...

Pooideae species. While for several species the most important allergens (group 1 and group 5) have been identified, other allergens have either not been identified or sequence data are still missing. We have used mass spectrometry (MS) together with genetic and immunological methods to identify allergens in various grass pollen extracts. Methods: Pollen extracts of 6 different grass species (P...

In recent years, thanks to advances in molecular biology, allergological diagnosis has improved and specific IgE (sIgE) against an allergenic source has been transformed into sIgE against an allergenic protein or glycoprotein. This change, which has resulted in a more precise diagnosis of sensitisation, could explain the different dangers of certain molecular sensitisations and in many cases cr...

PURPOSE OF REVIEW The purpose of this paper is to review and discuss studies on molecular diagnosis in fruit and vegetable allergy. RECENT FINDINGS Celeriac, carrot and tomato are the most prevalent allergenic vegetables, whereas fruit allergy is mainly induced by apple, peach and kiwi. Component-resolved molecular diagnosis has been recently applied in two well-defined patient groups with ki...

PURPOSE OF REVIEW Component-resolved diagnostics makes use of defined allergen molecules to analyse IgE-mediated sensitizations at a molecular level. Here, we review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations. RECENT FINDINGS Component resolution in HVA has moved from single molecules to ...