Purpose To investigate changes in volumes of extraocular muscle (EOM) compartments in unilateral superior oblique (SO) palsy using magnetic resonance imaging (MRI). Methods High-resolution, surface-coil MRI was obtained in 19 patients with unilateral SO palsy and 19 age-matched orthotropic control subjects. Rectus EOMs and the SO were divided into two anatomic compartments for volume analysis...

Abstract Compartmental epidemiological models are, by far, the most popular in study of dynamics related with infectious diseases. It is, therefore, not surprising that they are frequently used to current COVID-19 pandemic. Taking advantage real-time availability data, we perform a compartmental model fitting analysis portuguese case, using an online open-access platform integrated capability s...

In ectomycorrhizae, the relative abilities of mycobiont and host plant to take up and store inorganic nutrients are not easily determined due to the intimate physical relationship of the two components forming the association. Since compartmental analysis of solute elution can estimate cellular compartment pool sizes and unidirectional fluxes across membranes, we have used this method to study ...

The method of graphical analysis for the evaluation of sequential data (e.g., tissue and blood concentrations over time) in which the test substance is irreversibly trapped in the system has been expanded. A simpler derivation of the original analysis is presented. General equations are derived that can be used to analyze tissue uptake data when the blood-plasma concentration of the test substa...

In-vivo studies using animal model were carried out to investigate the pharmacokinetic profile of passive and iontophoretically delivered lisinopril. Serum concentration versus time profiles from intravenous (IV), oral and iontophoretic routes were analyzed using non-compartmental analysis using TOPFIT ver. 2.0. Pharmacokinetic parameters such as AUC0–inf, terminal elimination rate constant (λz...

A new mathematical framework is introduced for combining the linear compartmental models used in pharmacokinetics with the spatiotemporal distributions of activity that are measured in single photon emission computed tomography (SPECT) and PET imaging. This approach is global in the sense that the compartmental differential equations involve only the overall spatially integrated activity in eac...

Anatomical studies demonstrate selective compartmental innervation of most human extraocular muscles (EOMs), suggesting the potential for differential compartmental control. This was supported by magnetic resonance imaging (MRI) demonstrating differential lateral rectus (LR) compartmental contraction during ocular counterrolling, differential medial rectus (MR) compartmental contraction during ...

Amprenavir is a protease inhibitor that has been shown to have secondary peaks postulated to be due to enterohepatic recycling. We propose a model to describe the pharmacokinetics of amprenavir which accommodates the secondary peak(s). A total of 82 healthy human immunodeficiency virus (HIV)-seronegative subjects were administered a single 600-mg dose of amprenavir as part of adult AIDS Clinica...