نتایج جستجو برای: colorectal cancers
تعداد نتایج: 164124 فیلتر نتایج به سال:
Colorectal cancers with microsatellite instability (MSI) represent 15% of all colorectal cancers, including Lynch syndrome as the most frequent hereditary form of this disease. Notably, MSI colorectal cancers have a higher density of tumor-infiltrating lymphocytes (TIL) than other colorectal cancers. This feature is thought to reflect the accumulation of frameshift mutations in sequences that a...
OBJECTIVES The purpose of this prospective study was to evaluate the association between bilateral inguinal hernias and colorectal cancers. PURPOSE Inguinal hernias are one of the most common subjects in surgical practice and have been known to be associated with some other pathologies since 1831. Although there are some series in literature reporting the association of colorectal cancers wit...
BACKGROUND Multiple cancers may occur in an individual because of a genetic predisposition, environmental exposure, cancer therapy, or immunological deficiency. Colorectal cancer is one of the most commonly diagnosed cancers, and inherited factors play an important role in its aetiology. AIMS To characterise the occurrence of multiple primary cancers in patients diagnosed with colorectal canc...
Synchronous colorectal cancers (SCRCs) have been increasingly diagnosed due to emerging diagnostic modalities. The presence of three or more synchronous colorectal cancers has, however, only rarely been reported. A 76-year-old white man presented for management of two concurrent colorectal adenocarcinomas in the left colon evidenced on total colonoscopy. Preoperative abdominal ultrasonography a...
The CpG Island Methylator Phenotype (CIMP) is fundamental to an important subset of colorectal cancer; however, its cause is unknown. CIMP is associated with microsatellite instability but is also found in BRAF mutant microsatellite stable cancers that are associated with poor prognosis. The isocitrate dehydrogenase 1 (IDH1) gene causes CIMP in glioma due to an activating mutation that produces...
and melena in 2010. His past history included resection of a sigmoid carcinoma in 1997. Colonoscopies in 1999 and 2000 had shown polyps. A repeat colonoscopy for anemia in2001had shown two interval cancers in the ascending and transverse colon, and a right hemicolectomy had been performed. Surveillance colonoscopies in 2002, 2003, and 2005 showed only hyperplastic polyps in 2003. Colonoscopy in...
Nutrition in gastrointestinal (GI) cancer is an important part of treatment protocol. A detailed study published guidelines necessary to prevent pre-operative malnutrition and sustain peri-operative nutrition such patients. In this review, we discuss propose recommendations based on established suit the Indian population with different GI cancers (gastric, esophageal, pancreatic, colorectal hep...
BACKGROUND The outcome of colorectal cancer varies depending on ethnic origin. Egyptian colorectal carcinoma is surprisingly young-age disease with high proportion of rectal and advanced stage cancers. METHODS We characterized 69 sporadic Egyptian colorectal cancers for promoter methylation at 24 tumor suppressor genes, microsatellite instability, and expression of mismatch repair, p53, and β...
BACKGROUND Non-steroidal anti-inflammatory drugs can reduce the risk of colorectal cancer. Reportedly, mRNA expression of cyclooxygenase-2 (COX-2) is elevated in human colorectal cancers compared with accompanying normal mucosa. The present study was undertaken to establish a simple analytical procedure to quantify COX-2 expression levels and to characterize COX-2 expression levels in human col...
In metastatic colorectal cancers, tumor cells are disseminated prior to surgical resection of the primary tumor but remain dormant until proper colonization mechanisms are activated. To identify the colonization mechanisms of the metastatic tumors, we conducted a pairwise comparison between primary colorectal cancers and metastatic tumors (n=12 pa...
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