Colon cancer is one of the leading causes morbidity and mortality throughout world. Some most common presenting signs are a change in bowel habits, alteration fecal contour or consistency, blood stool, fatigue, weight loss. However, it may present insidiously. This case an 81-year-old female with Clostridium septicum bacteremia as primary sign metastatic colon cancer. In further literature revi...

We measured the in vitro protein-tyrosine kinase activity of pp60C-" from human colon carcinoma cell lines and tumors. The activity of pp6O¢-'Cl from six of nine carcinoma cell lines was higher (on average, fivefold as measured by enolase phosphorylation, or eightfold as measured by autophosphorylation) than that of pp6OC" from normal colonic mucosal cells, or human or rodent fibroblasts. Simil...

Increased expression levels of survivin are crucial for invasion activity in several types of human cancer, including colon carcinoma. However, the molecular mechanisms whereby survivin regulates cancer invasion have not been completely elucidated. To the best of our knowledge, this study is the first to investigate the role of matrix metalloprotease‑7 (MMP‑7) in cell invasion that is induced b...

PURPOSE In the present study, we examined the expression of a multifunctional cytokine, interleukin 8 (IL-8), and its receptors, CXCR1 and CXCR2, in human colon carcinoma cells with different metastatic potentials and determined their role in modulating phenotypes associated with metastasis. EXPERIMENTAL DESIGN IL-8, CXCR1, and CXCR2 protein and mRNA expression were examined using ELISA, immu...

Drug resistance is a major cause of failure in cancer chemotherapy. Therefore, identification and combined use of adjuvant compounds that can overcome drug resistance may improve the efficacy of cancer therapy. We screened extracts of Verticillium species-infected mushrooms for antitumor compounds and identified the compound Verticillin A as an inducer of hepatoma cell apoptosis in vitro and an...

Four cases of coexisting tuberculosis and carcinoma of the colon (CTCC) are reported. All the patients were female and the mean age was 49 +/- 11 years. The tumour involved the right colon in three patients and the distal transverse colon in the other. The two lesions coexisted at the same site in two patients. Mucinous carcinoma was the predominant type seen in three patients. The characterist...

BACKGROUND AND OBJECTIVE Colon cancer is one of the most common malignant tumors, and its pathogenesis is not fully understood. Transcriptional silencing by DNA methylation is believed to be an important mechanism of carcinogenesis. E-cadherin can suppress tumor cell invasion and metastasis, and is considered as an invasion/metastasis suppressor gene. Inactivation of E-cadherin gene often occur...

BACKGROUND Mesorectal margin tumour involvement is a predictor of local recurrence in rectal carcinoma and an indication for postoperative radiotherapy in suitable patients. However, the prevalence of non-peritonealised surgical margin involvement in ascending colon carcinoma is unknown. AIMS To test the hypothesis that retroperitoneal surgical margin (RSM) tumour involvement occurs in distal...