Multi-storey buildings require mitigation of consequences unexpected or accidental events, to prevent disproportionate collapse after an initial damage. Cross-laminated timber (CLT) in platform-type construction is increasingly used for multi-storey buildings, however, the behaviour and alternative load paths (ALPs) are not fully understood. A 3D non-linear component-based finite element model ...

The DNA-damage checkpoint kinase Chk1 is essential in higher eukaryotes due to its role in maintaining genome stability in proliferating cells. CHK1 gene deletion is embryonically lethal, and Chk1 inhibition in replicating cells causes cell-cycle defects that eventually lead to perturbed replication and replication-fork collapse, thus generating endogenous DNA damage. What is the cause of repli...

BACKGROUND Transcatheter aortic valve replacement has emerged as a promising therapy for treatment of severe aortic stenosis. Although it has been shown that these valves can be safely delivered and implanted, studies of valve longevity are lacking because of the infancy of the technology. Particularly, the effects of stent crimping on the valve's leaflets have not yet been sufficiently investi...

In this paper we study the response of 2D framed structures made of reinforced concrete to the sudden removal of columns. For comparative reasons, the 2D frames are considered as part of 3D structures with same overall structural mass and external load potential. In particular, we study two sets of 2D frames, with different height-bay ratio λ of the structural cells. Each set counts 3 frames wi...

rosy apple aphid, dysaphis plantaginea (passerini), with worldwide distribution is an important pest of apple orchards. host plant resistance is an essential component of integrated management of this insect pest. we investigated the resistance of seven apple cultivars, malus domestica (borkhausen), namely granny smith, starkrimson, golden smoothee, red delicious, golden delicious, boshghabi, a...

This paper uses a finite element model to investigate the stability of the Twin-Towers of the World Trade Center, New York for a number of different fire scenarios. This investigation does not take into account the structural damage caused by the terrorist attack. However the fire scenarios included are based upon the likely fires that could have occurred as a result of the attack. A number of ...

Across many industries damage events leading to a breach in structural integrity continue to occur. An area where this can lead to particularly unsafe conditions is in the maritime environment, where it may be difficult to rescue crew and cargo. In order to improve structural safety through design for the survivability or to assess the residual strength of a damaged vessel in an emergency respo...