Collagen fiber re-alignment and uncrimping are postulated mechanisms of structural response to load. It has been suggested that fibers re-orient in the direction of load and then "uncrimp" before collagen is tensioned and that in general, the structure is a result of the function tendons perform. However, little is known about how fiber re-alignment and uncrimping change in response to load, ho...

this syndrome is a genetical disorder with symptoms result from deficit in the formation of connective tissue, especially collagen fiber biosynthesis. in these patients, there is hyperelasticity and fragility of the skin and mucosa. injuries sever bleeding, internal bleeding and hemartrosis may be seen in these patients. wounds leave scars after healing. there is recurrent dislocation of the jo...

Collagen-based dressings achieve excellent repair of the skin during metical cosmetology, which has received a lot attention recently. Although great progress been made on using biomass fiber as dressing carrier, more research is required developing novel fibers because limitations (i.e., high cost and complex processing) existing materials. In this study, adsorption behaviors two human-like co...

To study the structural contribution of perimysial collagen fibers to the passive mechanics of ventricular myocardium, we modeled the coiled fibers as helical springs using elastica theory to represent the fibers as initially curved, inextensible rods that could bend and twist. The extensional behavior in the physiological range of left ventricular (LV) pressures was dependent on structural par...

Collagen gels are widely used in experiments on cell mechanics because they mimic the extracellular matrix in physiological conditions. Collagen gels are often characterized by their bulk rheology; however, variations in the collagen fiber microstructure and cell adhesion forces cause the mechanical properties to be inhomogeneous at the cellular scale. We study the mechanics of type I collagen ...

The turbidity of most biologic tissues hinders the use of lasers for diagnostic and therapeutic purposes. Hyperosmotic agents such as glycerol have been used to alter the optical scattering properties of turbid tissues. The mechanism of this effect, "optical clearing", however, remains incompletely understood. Multiphoton microscopy utilizing second harmonic generation can be used to monitor co...

We present an automated and systematic two-dimensional discrete Fourier transform (2D-FFT) approach to analyze collagen fiber organization through the use of second harmonic generation (SHG) microscopy. Average orientations of individual domains and Ising-like order parameters introduced to characterize the correlation between orientations of adjacent domains may be used to quantitatively chara...

OBJECTIVE To assess the potential of adipose-derived nucleated cell (ADNC) fractions to improve tendon repair in horses with collagenase-induced tendinitis. ANIMALS 8 horses. PROCEDURES Collagenase was used to induce tendinitis in the superficial digital flexor tendon of 1 forelimb in each horse. Four horses were treated by injection of autogenous ADNC fractions, and 4 control horses were i...

The mechanical properties of type I collagen gel vary due to different polymerization parameters. In this work, the role of crosslinks in terms of density and stiffness on the macroscopic behavior of collagen gel were investigated through computational modeling. The collagen fiber network was developed in a representative volume element, which used the inter-fiber spacing to regulate the crossl...

Among mammalian soft tissues, articular cartilage is particularly interesting because it can endure a lifetime of daily mechanical loading despite having minimal regenerative capacity. This remarkable resilience may be due to the depth-dependent mechanical properties, which have been shown to localize strain and energy dissipation. This paradigm proposes that these properties arise from the dep...