Rosmarinic acid (RA) is an ester of caffeic acid and 3, 4-dihydroxyphenyllacticacid. It is commonly found in Coleus blumei, Salvia officinalis, Melissa officinalis and Rosmarinus officinalis. The biosynthesis of RA starts with precursor molecules L-phenylalanine and L-tyrosine. Simulation of RA biosynthetic pathway was done using Gepasi Software, includes the reaction kinetics of each step of t...

Coleus tuberosus is classified as a local vegetable of the family Lamiaceae, the subfamily Nepetoideae and tribe Ocimeae. Ethanolic extract peel of Coleus tuberosus (EEPC) and ethanolic extract flesh of Coleus tuberosus (EEFC) were evaluated for their antioxidant activities by using ferric thiocyanate (FTC) and thiobarbituric acid (TBA) method. Cancer chemopreventive activities were evaluated b...

Water extract of the leaves of Coleus aromaticus  Benth. Was tested for its antiurolithiatic activity against calcium oxalate stones in male albino rats. Calcium oxalate stones were induced by feeding 3% w/w sodium oxalate along with normal feed. The water extract of coleus aromaticus (0.5 g/kg and 1.0 g/kg, once, orally for 30 days) was found to be effective in reducing deposition of calcium o...

Natural products continue to play a significant role in the detection and advancement of new pharmaceuticals as clinically useful drugs and as raw materials to produce synthetic drugs, or as lead compound from which a totally synthetic drug is designed. Coleus is a member of the mint family and native to India and grows in the subtropical temperate climates of India, Nepal, Thailand and Sri Lan...

Latar Belakang: Akumulasi asprin menghasilkan senyawa reaktif berupa radikal bebas yang menginduksi terjadinya stres oksidatif sehingga akan mepengaruhi fungsi ginjal. Ekstrak etanol daun C. blumei Benth mengandung metabolit sekunder golongan alkaloid, flavonoid, saponin, fenol, antrakuinon, tanin, dan steroid memiliki kemampuan mencegah pembentukan bebas, antiinflamasi memperbaiki Penelitian i...