A patient with infectious mononucleosis complicated by acute haemolytic anaemia is described. The patient had, in addition to non-specific cold agglutinins in the serum, a positive Donath-Landsteiner reaction in the absence of syphilis. The association of a positive Donath-Landsteiner reaction with haemolytic anaemia in infectious mononucleosis has been described only once before.

The fetal antigen i has been demonstrated by indirect immunofluorescence on cord erythrocytes and placental trophoblast. A patient with disseminated choriocarcinoma developed high-tire anti-i cold agglutinins, and minor elevation of anti-i titres was seen in four out of six further patients with treated choriocarcinoma. In normal pregnant women, 6% showed similar increases in anti-i titres.

Lymphocytes that formed rosettes with sera made to the serum macroglobulins human red cells in the cold were observed detected the same proteins on the lymphoin the peripheral blood of four patients cyte surface. Evidence was obtained that with chronic cold agglutinin disease. Simthe rosette test underestimated the numilar rosettes were not observed in normals ber of cells bearing the specific ...

709 The patient was kept warm in bed and the rash gradually faded during the course of a week. The discoloration lightened through red and brown, and on discharge from hospital only slight residual staining remained. There was no evidence of a falling haemoglobin, and after discharge she suffered no further symptoms. The cold agglutinins, however, were still present after a month. When reviewed...

introduction autoimmune haemolytic anemia (aiha) is a complex process characterized by an immune reaction against red blood cell self-antigens. the analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. this paper was written to alert technologists and pathologists to the presence of cold agglutinins and its ef...