Much adult physical inactivity research ignores early-life factors from which later influences may originate. In the 1958 British birth cohort (followed from 1958 to 2008), leisure-time inactivity, defined as activity frequency of less than once a week, was assessed at ages 33, 42, and 50 years (n = 12,776). Early-life factors (at ages 0-16 years) were categorized into 3 domains (i.e., physical...

BACKGROUND Since the 1930s, the environment has become increasingly obesogenic, leading to rising rates of adiposity and socioeconomic inequalities in adiposity. Building on studies comparing body mass index (BMI) for cohorts born over a period of 20 years, we examine the social patterning of BMI and central adiposity for three cohorts born over a 40-year period. METHODS Using data from the W...

there are limited documents about hiv patients switched to second-line antiretroviral therapy (art) in resource-limited countries. we aimed to assess the efficacy of second-line art for hiv patients following first-line art failure. this was a cohort study of hiv/aids patients with first-line art treatment failure switched to second-line art between january 2004 and march 2014, who followed for...

objective: bipolar disorder is strongly associated with suicidal ideations, attempts and commissions. although several studies have been conducted on suicide risk factors in patients with bipolar disorder worldwide, a comprehensive study has not been reported from iran. methods: patients with bipolar disorder type i, hospitalized in iran hospital of psychiatry since may 2008 to august 2011 were...