In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

The marine dinoflagellate Cochlodinium polykrikoides is one of the most common ichthyotoxic species that causes harmful algal blooms (HABs), which leads to ecological damage and huge economic loss in aquaculture industries. Cyclophilins (CYPs) belong to the immunophilin superfamily, and they may play a role in the survival mechanisms of the dinoflagellate in stress environments. In the present ...

The abilityof Cochlodinium polykrikoides to use various nitrogen, phosphorus, and selenium compounds as a nutrient source was examined in batch culture experiments to obtain biological information on the mechanism of C. polykrikoides bloom formation. C. polykrikoides grew using a variety of organic or inorganic nitrogen sources except for L-proline. Maximum yields of C. polykrikoides were obtai...