نتایج جستجو برای: cobra venom

تعداد نتایج: 10725  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Freek J Vonk Nicholas R Casewell Christiaan V Henkel Alysha M Heimberg Hans J Jansen Ryan J R McCleary Harald M E Kerkkamp Rutger A Vos Isabel Guerreiro Juan J Calvete Wolfgang Wüster Anthony E Woods Jessica M Logan Robert A Harrison Todd A Castoe A P Jason de Koning David D Pollock Mark Yandell Diego Calderon Camila Renjifo Rachel B Currier David Salgado Davinia Pla Libia Sanz Asad S Hyder José M C Ribeiro Jan W Arntzen Guido E E J M van den Thillart Marten Boetzer Walter Pirovano Ron P Dirks Herman P Spaink Denis Duboule Edwina McGlinn R Manjunatha Kini Michael K Richardson

Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of a venomous snake, the king cobra (Ophiophagus hannah), and compared it, togeth...

Journal: :Toxicon : official journal of the International Society on Toxinology 2015
Andreas H Laustsen José María Gutiérrez Brian Lohse Arne R Rasmussen Julián Fernández Christina Milbo Bruno Lomonte

The venom proteome of the monocled cobra, Naja kaouthia, from Thailand, was characterized by RP-HPLC, SDS-PAGE, and MALDI-TOF-TOF analyses, yielding 38 different proteins that were either identified or assigned to families. Estimation of relative protein abundances revealed that venom is dominated by three-finger toxins (77.5%; including 24.3% cytotoxins and 53.2% neurotoxins) and phospholipase...

2003
S. Meenatchisundaram A. Michael

Aqueous extracts of Mucuna pruriens seeds were tested for their activity on various pharmacological effects like lethality, phospholipase activity, edema forming activity, fibrinolytic activity and haemorrhagic activity of of cobra and krait venoms. The aqueous extract displayed a significant inhibitory effect on the lethality, phospholipase activity, edema forming activity, fibrinolytic activi...

Journal: :The Journal of biological chemistry 1985
D Lombardo E A Dennis

Manoalide, an unusual nonsteroidal sesterterpenoid recently isolated from sponge, antagonizes phorbol-induced inflammation but not that induced by arachidonic acid, suggesting that manoalide acts prior to the cyclooxygenase step in prostaglandin synthesis, possibly by inhibiting phospholipase A2. We have now studied the inhibitory effect of manoalide on a homogeneous preparation of phospholipas...

Journal: :Quarterly Journal of Experimental Physiology 1912

Journal: :Proceedings of the National Academy of Sciences 1970

Journal: :Indian Journal of Ophthalmology 2020

Journal: :British journal of anaesthesia 1977
R W Naphade R N Shetti

Cobra venom consists of a neurotoxin which is responsible for respiratory paralysis simulating that associated with a non-depolarizing muscle relaxant. A combination of artificial respiration and neostigmine has been useful in resuscitating a child bitten by a snake.

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