Factors affecting the coagulant activity of two different prothrombin complex concentrates have been investigated using a sensitive in vitro assay developed in this laboratory. One concentrate contained substantial amounts of potentially thrombogenic material, while the other, which was deliberately fortified with antithrombin III and heparin during production, was judged to be relatively nonth...

Conventional water treatment consumes large quantities of coagulant and produces even greater volumes of sludge. Coagulant recovery (CR) presents an opportunity to reduce both the sludge quantities and the costs they incur, by regenerating and purifying coagulant before reuse. Recovery and purification must satisfy stringent potable regulations for harmful contaminants, while remaining competit...

The natural coagulant Moringa oleifera (MO) is considered to be an efficient coagulant with some advantages over chemical coagulants. Fluoride removal, using MO seed extract was investigated. The influence of MO dosage, initial F concentration, and pH were determined and modeled using the Box-Behnken design response surface methodology. With a constant initial F concentration, it was found that...

The removal of cadmium and turbidity from contaminated soil-washing water was studied by Electroflotation (EF) at the laboratory scale by using sodium lauryl sulfate (SLS) as an anionic surfactant, and calcium hydroxide (Ca(OH)2) as a coagulant. The stoichiometric cadmium to collector (SLS) and coagulant (Ca(OH)2) ratio was 1:4.5. Significant removal of cadmium (100 %, not detected in the resid...

Optimal amounts of demineralized bone matrix possess the ability to coagulate platelet-free heparinized, citrated, and oxalated blood plasmas of guinea pigs. Clotting constituents become denatured in contact with the insoluble coagulant proteins. Quantities in excess of optimal modify plasma so that it does not gel when thrombin is added. The newly described coagulant effects are not restricted...

In vitro evaluation of prothrombin complex concentrates in a thrombin generation assay, using DAPA and purified components of the prothrombinase complex, demonstrated significant levels of coagulant-active "phospholipid replacing" activity. Quantification of this activity showed a significant correlation (r = 0.8747, p less than 0.01) with thrombogenicity measured in vivo in a stasis model in r...

BACKGROUND AND OBJECTIVES A high level of coagulant factor VIII is a well known risk factor for venous thromboembolism, but most studies have enrolled patients under 70 years old. This study aimed to test the hypothesis that an association also exists in the elderly. DESIGN AND METHODS This hospital-based case-referent study took place at the Department of Internal Medicine and Chest Diseases...

Issam Najm, Carol Tate, and Douglas Selby he upcoming Disinfectants/Disinfection ByProducts (D/DBP) Rule recognizes that a greater reduction in the total organic carbon (TOC) concentration of a natural water supply may appreciably reduce the concentrations of known and unknown DBPs formed during chlorination. Thus, the D/DBP Rule requires that conventional surface water treatment plants use enh...