Extracellular signal regulated kinase½ (ERK1/2) signaling is critical to endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy. This study was to investigate ERK1/2 signaling and hypertrophic response to ET-1 stimulation in cardiomyocytes (CMs) from spontaneous hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Primary neonatal SHR and WKY CMs were exposed to ET-1 for up to 24 hr...

BACKGROUND The sinoatrial node is the main impulse-generating tissue in the heart. Atrioventricular conduction block and arrhythmias caused by sinoatrial node dysfunction are clinically important and generally treated with electronic pacemakers. Although an excellent solution, electronic pacemakers incorporate limitations that have stimulated research on biological pacing. To assess the suitabi...

BACKGROUND Pluripotent stem cells represent one promising source for cellular cardiomyoplasty. In this study, we used cardiac magnetic resonance to examine the ability of highly enriched cardiomyocytes (CMs) derived from murine embryonic stem cells (ESC) to form grafts and improve contractile function of infarcted rat hearts. METHODS AND RESULTS Highly enriched ESC-CMs were obtained by induci...

AIM Congenital Malformations (CMs) represent a challenge especially for developing countries. Data about CMs in Albania are rather scarce. In this context, our aim was to assess the prevalence and factors associated with CMs in Tirana, the capital of Albania. METHODS Information on all CMs at birth during 2011-2013 was retrieved from the National CM Surveillance System. For each CM case, thre...

Purpose – With academic institutions’ adoption of Course/Learning Management Systems (CMS), librarians are increasingly providing content through this delivery method. This study aims to identify practical information for librarians considering CMS content development or re-evaluation of online offerings. Design/methodology/approach – Academic libraries with health sciences information literacy...

BACKGROUND Establishment of a biological pacemaker is expected to solve the persisting problems of a mechanical pacemaker including the problems of battery life and electromagnetic interference. Enhancement of the funny current (If) flowing through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and attenuation of the inward rectifier K+ current (IK1) flowing through inward r...

Intravenous colistin methanesulfonate (CMS) is increasingly the last line of defense for multidrug-resistant gram-negative bacteria and is now being used as “salvage” therapy in critically ill patients (1, 7, 9, 11). CMS is converted in vivo to colistin, and these two entities have substantially different pharmacokinetics, antibacterial activities, and toxicities (7), and therefore it is import...

different approaches have been presented for estimating river environmental flow which hydrological approach has a lot addressed because of its need to access to limited data and moderately rapid assessment. this approach incorporates various methods therefore comparison between results of different methods is essential. the objective of this study is to investigate and compare the consequences...

Major depression is known to be associated with cardiovascular abnormalities, and oxidative stress has been suggested to play a role. We tested the hypothesis that antidepressant treatment reduces oxidative stress and endothelial dysfunctions in the chronic mild stress (CMS) model of depression in rats. Rats with >30% reduction in sucrose intake after 4 wk of CMS were defined in the study as CM...

PURPOSE Use of concomitant medicines (CMs) is a common practice in people with epilepsy, as comorbidity in this group is frequent. Comedication, especially if it is self-administered, may pose significant hazards due to potential interactions. Some attention has been given to use of CMs in older patients with epilepsy but the CM habits of younger patients are much less known. The purpose of thi...