C arbon used to be so plain, so ordinary, so common. In its two atomic forms based on chemical bonding, graphite (sp 2) and diamond (sp 3), it certainly has its charms, but it was largely ignored in its unalloyed states for high-tech applications until the discovery of stable, nanoscale structures starting with buckyballs (C 60) in 1985. However, how to cheaply mass produce C 60 , also known as...

The consumption of red meat is a risk factor in human colorectal cancer (CRC). One hypothesis is that red meat facilitates the nitrosation of bile acid conjugates and amino acids, which rapidly convert to DNA-damaging carcinogens. Indeed, the toxic and mutagenic DNA adduct O(6)-carboxymethylguanine (O(6)-CMG) is frequently present in human DNA, increases in abundance in people with high levels ...

The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear. Using electron microscopy, we have determined the structure of the CMG in the presence of ATPγS and a DNA duplex bearing a 3' single-stranded tail. The structure shows that the MCM subunits of the CMG bind preferentially to single-stra...

of Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy NONLINEAR CONTROL FOR SYSTEMS CONTAINING INPUT UNCERTAINTY VIA A LYAPUNOV-BASED APPROACH By William MacKunis May 2009 Chair: Dr. Warren E. Dixon Major: Aerospace Engineering Controllers are often designed based on the assumption that a c...

Activation of the vitronectin receptor αvβ3 and the phosphorylation of extracellular signal‑regulated kinase (ERK)1/2 are critical events during tumor development and progression. The aim of the present study was to investigate the effects of WD‑3, a formula used in traditional Chinese medicine, on integrin αvβ3 and ERK1/2 expression in vivo using a nude mouse‑human gastric cancer xenograft mod...

BACKGROUND AND OBJECTIVES Gemcitabine (Gem) is far from satisfactory as the first-line regimen for pancreatic cancer, and the emergence of albumin nanoparticles offers new hope for the delivery of Gem. In this study, Gem-loaded human serum albumin nanoparticles (Gem-HSA-NPs) were successfully synthesized, characterized, and tested on a BxPC-3 cell line both in vitro and in vivo. MATERIALS AND...

PURPOSE The purpose of this study is to retrospectively compare the efficacy and tolerability between three regimens for first-line chemotherapy-gemcitabine plus capecitabine (GEM-X), gemcitabine plus erlotinib (GEM-T), and gemcitabine monotherapy (GEM)-in patients with advanced pancreatic cancer. MATERIALS AND METHODS There was a total of 127 patients who underwent chemotherapy for pancreati...

The Computer Measurement Group, commonly called CMG, is a not for profit, worldwide organization of data processing professionals committed to the measurement and management of computer systems. CMG members are primarily concerned with performance evaluation of existing systems to maximize performance (eg. response time, throughput, etc.) and with capacity management where planned enhancements ...

The Computer Measurement Group, commonly called CMG, is a not for profit, worldwide organization of data processing professionals committed to the measurement and management of computer systems. CMG members are primarily concerned with performance evaluation of existing systems to maximize performance (eg. response time, throughput, etc.) and with capacity management where planned enhancements ...

The Computer Measurement Group, commonly called CMG, is a not for profit, worldwide organization of data processing professionals committed to the measurement and management of computer systems. CMG members are primarily concerned with performance evaluation of existing systems to maximize performance (eg. response time, throughput, etc.) and with capacity management where planned enhancements ...