A once-daily sustained-release preparation of theophylline (Theo-24) was compared to a twice-daily (bid) preparation (Theo-Dur). Fourteen subjects with asthma requiring daily therapy with theophylline were evaluated in a 30-day prospective study. Pulmonary function and serum levels of theophylline were measured. With the twice-daily preparation the mean variation over 12 hours between the maxim...

The authors report on the variability in the integrated quantity of free (unbound) plasma cisplatin (area under curve of plasma concentration versus time, AUC). The AUC was measured in 19 patients receiving cisplatin doses proportional to body surface areas (BSA), 30 mg/m2 over 1 hour. The relative standard deviation (RSD, population standard deviation divided by mean value) for the maximum fre...

OBJECTIVE This study was designed to demonstrate that alendronate (ALN)/vitamin D3 combination tablets (ALN/D5600) are bioequivalent to corresponding doses of ALN and vitamin D3 as individual tablets in healthy Taiwanese volunteers. METHODS In this open-label, randomized, 2-period, crossover study, 68 volunteers were randomized to a single ALN/D5600 combination tablet or corresponding doses o...

In this paper, we investigate offline and online algorithms for Round-UFPP, the problem of minimizing the number of rounds required to schedule a set of unsplittable flows of non-uniform sizes on a given path with non-uniform edge capacities. Round-UFPP is NP-hard and constant-factor approximation algorithms are known under the no bottleneck assumption (NBA), which stipulates that maximum size ...

The objective of these two open phase I clinical trials was the investigation of the bioavailability of five constituents from a hypericum extract containing tablet, which are discussed as the components contributing to the antidepressant action. Each trial included 18 healthy male volunteers who received the test preparation, containing 612 mg dry extract of St John's wort (STW-3, Laif 600), e...

BACKGROUND Statins are effective agents in the primary and secondary prevention of cardiovascular disease, but treatment response to statins varies among individuals. We analyzed multiple genetic polymorphisms and assessed pharmacokinetic and lipid-lowering responses after atorvastatin 80 mg treatment in healthy Korean individuals. METHODS Atorvastatin 80 mg was given to 50 healthy Korean mal...

glimepiride/metformin(2/500mg) is an oral antihyperglycemic agent for the treatment of type 2 diabetes. a generic glimepiride/metformin(2/500mg) fixed-dose combination(fdc) tablet was developed recently. this study was designed to collect data for submission to korean regulatory authorities to allow the marketing of the test formulation. we evaluated the comparative bioavailability and tolerabi...

in the current study, the effects of ethanol (etoh) on toxicokinetics of methamphetamine (ma) and its metabolite amphetamine (ap) were investigated. a single dose of ma hydrochloride at 15 mg/kg was given intragastrically, either alone (ma group; n = 8) or in conjunction with 3 g/kg etoh (ma+etoh group; n = 8) to rabbits. in placebo group, normal saline only was given (placebo group; n = 4). pl...

BACKGROUND Daptomycin is recommended for complicated skin and skin-structure infections. However, information on the penetration of daptomycin into skin is limited. Therefore, the aim of this in vivo investigation was to determine the pharmacokinetics and skin penetration of daptomycin in rats. MATERIALS AND METHODS Concentrations of daptomycin were determined by high-performance liquid chrom...

OBJECTIVE To compare the bioavailability of single dose ibuprofen 200 mg and pseudoephedrine hydrochloride 30 mg administered alone or in combination as an oral suspension. METHODS This was a single-center, randomized, single-dose, open-label, 3-period, crossover study. After an overnight fast (≥10 h), 18 healthy male subjects received either ibuprofen 200 mg (reference-A), pseudoephedrine 30...