The 2-TM-GxN family of membrane proteins is widespread in prokaryotes and plays an important role transport divalent cations. canonical signature motif, which also a selectivity filter, has composition Gly-Met-Asn. Some members though deviate from this composition, however no data are available as to whether any functional implications. Here we report the structural analysis CmaX protein pathog...

In a previous contribution to this journal (Froese et al. 2012), we refuted criticism of a simple method (Froese and Kesner-Reyes 2002) that derives information about the status of global stocks from global catch data. This method assumes that, for a given stock, the ratio of current catches to previous maximum catches (Cmax) is indicative of the likely current exploitation status of the stock....

We present some results attained with two variants of Bounded Dynamic Programming algorithm to solve the Fm9block9Cmax problem using as an experimental data the well-known Taillard instances. We have improved the best known solutions for 17 of Taillard’s instances, including the 10 instances from set 12. & 2011 Elsevier Ltd. All rights reserved.

This paper presents a framework taking advantage of both the flexibility of constraint programming and the efficiency of operations research algorithms for solving scheduling problems under various objectives and constraints. Built upon a constraint programming engine, the framework allows the use of scheduling global constraints, and it offers, in addition, a modular and simplified way to perf...

Hypericins, hyperforin and flavonoids are discussed as the main components contributing to the antidepressant action of St. John's wort (Hypericum perforatum). Therefore, the objective of the two open phase I clinical trials was to obtain pharmacokinetic data of these constituents from a hypericum extract containing tablet: hypericin, pseudohypericin, hyperforin, the flavonoid aglycone querceti...

OBJECTIVE To establish the bioequivalence of a 500 mg film-coated tablet of saquinavir mesylate (FCT SQV) to the 200 mg hard-capsule saquinavir mesylate (HC SQV), both boosted with ritonavir and administered under fed conditions. METHODS We carried out a multi-centre, open-label, randomized, two-sequence, four-period, two-treatment, replicated crossover study in 93 healthy men and 7 healthy w...

We present and apply a new simulation/optimization approach for singleand multiple-planning period problems in groundwater remediation. Instead of the traditional control locations for contaminant concentrations, \Ve use an LC>O norm as a global measure of aquifer contamination (CMAX). We use response-surface constraints to represent CMAX within the optimization model. We compare the performanc...

OBJECTIVE To evaluate the bioavailability of vitamin D in capsules as compared with oily drops in nuns living in a closed community with very low sun exposure. METHODS A randomized, 2 x 2 crossover, open clinical trial was conducted, with 18 nuns aged between 20 and 75 years. Samples were collected in the fasting state and at 4, 8, 12 and 24 hours following the administration of capsules and ...

Аннотация For two scheduling problems (O3||Cmax and AL3||Cmax) tight bounds of the optima localization intervals are found in terms of lower bounds (C̃ and Ĉ, respectively) computable in linear time. The main part of the proof was made with an aid of computer. As a by-product, we obtain linear-time approximation algorithms for solving these problems with worst-case performance ratios 4/3 and 5/3...