Defaults in a credit portfolio of many obligors or in an economy populated with firms tend to occur in waves. This may simply reflect their sharing of common risk factors and/or manifest their systemic linkages via credit chains. One popular approach to characterizing defaults in a large pool of obligors is the Poisson intensity model coupled with stochastic covariates. A constraining feature o...

The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic locus, and this remarkable genomic organization is highly conserved from teleosts to humans. These clustered Pcdhs are differentially expressed in individual neurons, they engage in homophilic trans-interactions as multimers and they are required for diverse neurodevelopmental processes, including neurite se...

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The paper introduces the reader to a new paradigm shift that is currently taking place in the data storage industry: the movement toward Clustered Storage architectures. Clustered Storage architectures are changing the rules of how data is stored and accessed. This paper discusses the trends that clearly define clustered storage architectures as the future of data storage, detail the requiremen...

With population ageing and reductions in family care, utilisation of formal long-term care for disabled people is growing in all high-income countries. Higher demand for formal services is emerging also because of people’s expectations for high-quality care. These factors are pushing up the cost of formal long-term care across OECD countries and raise questions about who should pay more promine...

We address the problem of constructing phylogenetic networks using two criteria: the number of cycles and the fit value of the network. Traditionally the fit value is the main objective for evaluating phylogenetic networks. However, a small number of cycles in a network is desired and pointed out in several publications. We propose a new phylogenetic network called CS-network and a method for c...

The Target infrastructure has been specially built as a storage and compute infrastructure for the information systems derived from Astro-WISE. This infrastructure will be used by several applications that collaborate in the area of information systems within the Target project. It currently consists of 10 PB of storage and thousands of computational cores. The infrastructure has been construct...

the radiobiological effects of high atomic number and energy (hze particles) ion beams are of interest for radioprotection in space and tumor radiotherapy. space radiation mainly consists of heavy charged particles from protons to iron ions, which is distinct from common terrestrial forms of radiation. hze particles pose a significant cancer risk to astronauts on prolonged space missions. with ...

We consider a multi-armed bandit setting that is inspired by real-world applications in e-commerce. In our setting, there are a few types of users, each with a specific response to the different arms. When a user enters the system, his type is unknown to the decision maker. The decision maker can either treat each user separately ignoring the previously observed users, or can attempt to take ad...