The serine proteases, cofactors and cell-receptor molecules that comprise the haemostatic mechanism are highly conserved modular proteins that have evolved to participate in biochemical reactions in blood coagulation, anticoagulation and fibrinolysis. Blood coagulation is initiated by exposure of tissue factor, which forms a complex with factor VIIa and factor X, which results in the generation...

alcium fluctuations in the bottom layer of a platelet mass are propagated upwards to determine the size of a blood clot, or thrombus, according to results from Nesbitt et al. presented on page 1151. Platelets adhere to substrates in the vessel wall through receptors such as GPIb and certain integrins. Initial receptor engagement stimulates Ca 2 ϩ spikes in the platelets that lead to firm, perma...

Dr. Nelson is an endoscopist, and his technique involves introducing a small Geiger counter through an esophagoscope (or sigmoidoscope) and recording counting rates over the surface of the organ being examined in a patient who has received 500 uc. Of p32 the day before the exam. A positive result is obtained when a clear increase in counting rate is observed at some area as the counter is moved...

The thrombotic response elicited by arterial injury or atherosclerosis varies widely between individuals; in some, diffuse coronary artery disease never triggers thrombotic occlusion, whereas others with limited disease experience myocardial infarction (MI) due to arterial thrombosis. Understanding the predictors for arterial thrombosis will improve tailored therapy for preventing and treating ...

Dental health care workers are increasingly called upon to provide quality dental care to individuals whose bleeding and clotting mechanisms have been altered by inherited or acquired diseases. This provides an opportunity for the dentist who is trained in the recognition of oral and systemic signs of altered hemostasis to assist in the diagnosis of the underlying condition. A number of dental ...

The topic of this thesis is the simulation of blood clotting using the Lattice Boltzmann method and taking into account the non-Newtonian behavior of blood. This kind of simulations could be used for the treatment of diseases like stenosis and aneurysms. Their field of application includes the diagnostic of the diseases, the planning of surgeries and the investigation of new medical treatment s...

receiving full dose heparin (A kaolin clotting time; 56, 29, and 19 seconds) and four had been considered to have equivocal lupus inhibitor tests. On testing of subsequent samples from three of the equivocal patients, one with a A kaolin clotting time of 29 seconds was found to have a definite lupus inhibitor while the two others (19 and 14 seconds) were negative. The A kaolin clotting time in ...

Drummond, Margaret C. (Emory University, Atlanta, Ga.) and Morris Tager. Enzymatic activities associated with clotting of fibrinogen by staphylocoagulase and coagulase-reacting factor and their inhibition by diisopropylfluorophosphate. J. Bacteriol. 83:975-980. 1962.-The chemical mechanism of fibrinogen clotting by staphylocoagulase and its plasma factor (CRF) involves a preliminary stage of pr...

The effects on clotting tests and platelet function of six months' continuous administration of the 19-norsteroid, progestogen-only contraceptive, norethisterone, have been studied in four groups of women. In a group of women who have not previously taken oral contraceptive no acceleration of clotting or platelet factors was found, but in contrast a tendency to reduced coagulability was observe...

A mathematical model has been proposed to study the effect of [TAME] esterase on blood clotting time. Using this model, clotting time was found to decrease by 30% with increasing plasma [TAME] esterase activity in a group of smokers. It is hypothesized that [TAME] esterase through its effect on Hageman factor could affect clotting time. However mechanism of clotting by [TAME] esterase remains t...