* Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL85000. We present the application of our knowledge visualization tool, VxInsight, to enable domain analysis for science and technology management within the enterprise. Data mining from sources of bibliographic information is used...

A variety of methods are developed for characterising the free energy landscapes of continuum, Landau-type free energy models. Using morphologies of lipid vesicles and a multistable liquid crystal device as examples, I show that the methods allow systematic study of not only the most relevant minimum energy configurations, but also the transition pathways between any two minima, as well as thei...

The standard view that creativity entails both originality and appropriateness leads to the paradox that experts who converge on one optimal solution are rated as no more creative than beginners who give many original solutions. This paper asserts that there is no one-size-fits-all definition of creativity; creativity must be assessed relative to the constraints and affordances of the task. The...

The energy landscapes of proteins are highly complex and can be influenced by changes in physical and chemical conditions under which the protein is studied. The redox enzyme cytochrome P450cam undergoes a multistep catalytic cycle wherein two electrons are transferred to the heme group and the enzyme visits several conformational states. Using paramagnetic NMR spectroscopy with a lanthanoid ta...

Landscapes’ theory provides a formal framework in which combinatorial optimization problems can be theoretically characterized as a sum of a especial kind of landscape called elementary landscape. The elementary landscape decomposition of a combinatorial optimization problem is a useful tool for understanding the problem. Such decomposition provides an additional knowledge on the problem that c...

Humanity shapes freshwater flows and biosphere dynamics from a local to a global scale. Successful management of target resources in the short term tends to alienate the social and economic development process from its ultimate dependence on the life-supporting environment. Freshwater becomes transformed into a resource for optimal management in development, neglecting the multiple functions of...

A common view in evolutionary biology is that mutation rates are minimised. However, studies in combinatorial optimisation and search have shown a clear advantage of using variable mutation rates as a control parameter to optimise the performance of evolutionary algorithms. Much biological theory in this area is based on Ronald Fisher's work, who used Euclidean geometry to study the relation be...

Terrain reconstruction from images is an ill-posed, yet commonly desired Structure from Motion task when compositing visual effects into live-action photography. These surfaces are required for choreography of a scene, casting physically accurate shadows of CG elements, and occlusions. We present a novel framework for generating the geometry of landscapes from extremely noisy point cloud datase...

As community dwelling populations of older people and those living with chronic life limiting conditions continue to grow, the role everyday geographies, particularly based settings activities, in supporting health wellbeing has become a focus both research policy development. The therapeutic landscape scholarship provides holistic view how place promotes wellbeing, recent years expanded its fr...