There is considerable evidence that a adrenergic mechanisms within medulla and hypothalamus play a role in cardiovascular regulation (1-4). Apart from the action on medullary mechanisms, clonidine has been reported to elicit hypotension by an action on hypothalamic a-adrenergic receptors and the possible mechanism of action of the drug applied into the hypothalamus has hitherto been discussed i...

OBJECTIVE The study goal was to determine whether clonidine treatment of neonatal abstinence syndrome (NAS) would result in a better neurobehavioral performance compared with morphine. METHODS This pilot study prospectively enrolled infants ≥ 35 weeks' gestational age admitted for treatment of NAS. After informed consent was obtained, infants were randomized to receive morphine (0.4 mg/kg per...

Treatment outcomes were compared for 2 groups of subjects detoxified from methadone using clonidine. One group of 12 subjects was encouraged to continue in treatment with naltrexone, while the other 12 subjects did not have naltrexone treatment available. Results suggested that those subjects who had naltrexone available were more successful at completing the 10 day detoxification treatment and...

Clonidine in paediatric anaesthesia: Pharmacokinetic and pharmacodynamic aspects. Henrik TG Bergendahl. Stockholm 2002. Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. Descending postjunctional noradrenergic antinociceptive pathways originating in the b...

the effect of clonidine, a central alpha2-adrenoreceptor agonist on reduction of anxiety, producing sedation and attenuation hemodynamic changes, were assessed during thissemi-experimental study in one of the hospitals of iran medical sciences university in tehran, 1994.   fifty surgical patients of either sex, 18-60 years of age, with asa physical status i or ii, gave informed consent to enter...

BACKGROUND Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain. Opioid intake in neuropathic pain patients is motivated by alleviation of both pain and allodynia. However, laboratory animal studies rely almost exclusively on reflexive withdrawal measures of allodynia. The authors examined the pharmacology of self-regulated intake of...

Eleven drug free patients meeting Research Diagnostic Criteria for Major Depressive Disorder have been treated with desipramine and given a clonidine infusion after 0, 1 and 3 weeks of treatment. The sedative and hypotensive effects of clonidine were significantly inhibited after three weeks of treatment with desipramine: a similar interaction was seen after one week of treatment although this ...

Many techniques and drug regimens, with partial or greater success, have been tried from time to time to eliminate the anxiety component and to prolong the postoperative analgesia during regional anesthesia. α 2 agonists like clonidine, dexmedetomidine are used as adjuvant to local anaesthetics in order to prolong the duration of spinal anaesthesia. They potentiate the effect of local anestheti...

The effects of pharmacological modulation of adrenergic receptors on colonic motor and sensory function are unclear. We studied 40 healthy volunteers in a single-blind design; 12 received saline, and the remaining 28 received either clonidine, yohimbine, phenylephrine, or ritodrine. A barostat-manometric assembly in the left colon recorded drug effects on fasting and postprandial motor function...