Web services have been developed and deployed for GIS applications. Client-server interaction in such applications is limited by the service provider, such as ArcWeb Service. This paper will discuss the needs from service requester which lead to the exploration on the design and manipulation of Web Service interface. It is likely that GIS Web Service promotes the separation of spatial feature a...

This paper examines a successful architectural design process, taking place over a period of seven years, which resulted in the delivery of a complex building meeting the aspirations of the client. Our analysis focuses on the mechanisms by which expectations about how a building will be experienced are created, shared, and resolved during the process of design. We find differences in the ways d...

Adaptive video streams, when competing behind a single bottleneck link, experience unstable video quality, underutilized links, and unfair distribution of bandwidth. Different classes of solution have been proposed. On client side, bitrate adaptation algorithms have been designed to minimize the video bitrate changes as well as attain as high bitrate as the network resources allow. On the serve...

It is still unclear what molecular forces drive chaperone-mediated protein folding. Here, we obtain a detailed mechanistic understanding of the forces that dictate the four key steps of chaperone-client interaction: initial binding, complex stabilization, folding, and release. Contrary to the common belief that chaperones recognize unfolding intermediates by their hydrophobic nature, we discove...

Hsp90 is an essential molecular chaperone required for the folding and activation of many hundreds of cellular "client" proteins. The ATP-dependent chaperone cycle involves significant conformational rearrangements of the Hsp90 dimer and interaction with a network of cochaperone proteins. Little is known about the mechanism of client protein binding or how cochaperone interactions modulate Hsp9...