Background: Pyrazolopyridines are heterocyclic compounds with nitrogen atoms in the ring, and they have been used as one of important pharmacophores drug design. Pyrazole derivatives synthesised applied pharmaceutical industry active drugs. The recent commercial success pyrazole COX-2 inhibitors has brought even more attention to significance this ring medicinal chemistry. Objective: This study...

Hydrazine and its derivatives, as harmful substances, seriously risk the health of humans environment. On basis admirable luminescent properties low biological harmfulness biphenyl moiety, a moiety can be combined with naphthalene ring via chalcone scaffold easily traced by nucleophilic group. Therefore, chalcones (BPCs) decorated various systems fluorescent sensors for hydrazine are synthesise...

In our research, new bis-α, β-unsaturated carbonyl compounds (Z2-Z4) were prepared via Claisen- Schmidt reaction, by the condensation of 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine (Z1) with different appropriate benzaldehyde, like (benzaldehyde, m-nitro benzaldehyde and o-chloro benzaldehyde) using 10% aqueous sodium hydroxide as a base. A simple efficient method has been applied for synthes...

Abstract A novel chalcone based pyrene (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(1,5a1-dihydropyren-1-yl)prop-2-en-1-one ( EIPDP ) has been successfully synthesized by Claisen-Schmidt condensation reaction. The molecular structure was optimized using density functional theory (DFT) at B3LYP/ 6-311++G(d,p) basis set. In addition, electrostatic potential (MEP) obtained to study the intramolecular cha...

Thesis AbstractBackground: Heterocyclic are known to have multiple applications in particular biomedical settings. Aim: The present study reports a convenient protocol for the design and synthesis of new heterocyclic compounds incorporating 1- hydroxy-naphthyl angular chromones bearing allylnaphthyl fragments. Materials Methods: versatile precursor 2-acetyl-4- allyl-1-hydroxy naphthalene was su...