scent sensitivities attribute to chemical fragrances is a lengthy one that includes everything from coughing, sneezing, gagging, shortness of breath, rhinitis and asthma attacks, to debilitating headaches, anxiety and dizziness. As a result, many workplaces and institutions — schools, hospitals and other government buildings — have some sort of scent-free or scent-reduction policy in place, whi...

Dimorphic cleistogamy is a specialized form of mixed mating system where a single plant produces both open, potentially outcrossed chasmogamous (CH) and closed, obligately self-pollinated cleistogamous (CL) flowers. Typically, CH flowers and seeds are bigger and energetically more costly than those of CL. Although the effects of inbreeding and floral dimorphism are critical to understanding the...

Contact lenses (CLs) are safe and commonly used method to correct the refractive errors. Rigid gas permeable (RGP) CLs are the first option in visual rehabilitation of patients with irregular cornea, helping to further delay surgical treatment and improve patients’ quality of life (QoL). Although, the practice of CLs in patients with irregular cornea must be based on evidence, there is a lack o...

Neuronal excitability in the adult brain is controlled by a balance between synaptic excitation and inhibition mediated by glutamate and GABA, respectively. While generally inhibitory in the adult brain, GABA(A) receptor activation is excitatory under certain conditions in which the GABA reversal potential is shifted positive due to intracellular Cl(-) accumulation, such as during early postnat...

A set of compounds (n = 30), including traditional cytochrome P450 substrates and compounds from AstraZeneca's compound library, was used in an experimental evaluation of an optimal design approach (ODA) for the estimation of enzyme kinetic parameters (CL(int), V(max), and K(m)). A depletion method previously shown to provide reliable results, the multiple depletion curves method (MDCM), was us...

Cutaneous Leishmaniasis (CL) is a tropical parasitic disease in humans, transmitted by sandflies. CL causes lesions on exposed parts of the body, potentially leaving life-long scars. The disease manifestations vary significantly, depending on parasite species. An estimated 0.7 1.3 million new cases occur worldwide annually. Recommendations on the treatment of CL currently have a weak evidence b...