PURPOSE This study tested whether individuals with at least 1 copy of the short (S) or long (L)(G) allele of the serotonin transporter gene-linked polymorphic region exhibit a greater incidence of premature ejaculation compared with L(A)L(A) individuals. MATERIALS AND METHODS The serotonin transporter gene-linked polymorphic region was genotyped in 82 men with lifelong premature ejaculation a...

INTRODUCTION Four premature ejaculation (PE) subtypes are distinguished on the basis of the duration of the intravaginal ejaculation latency time (IELT), its course in life, and frequency of complaints. Since the 1930s oral drug treatment and local anesthetics have been used to treat PE. Apart from dapoxetine, all currently available drugs to treat PE (SSRIs, clomipramine, and local anesthetics...

BACKGROUND Premature ejaculation is one of the most common sexual disorders. A large number of treatment options have been used so far for the treatment of this dysfunction and still a large number of experts are doing research in this field. Here we have tried to research on the beneficial effects of levosulpiride in the treatment of PE. METHODS Eighty-eight patients form different areas of ...

The history of premature ejaculation (PE) is a history of contrasting hypotheses, controversial debates among medical specialists and psychologists, many opinions, and ignorant and embarrassed patients, but it is also the history of independently thinking clinicians, and pioneering clinicians and neuroscientists, who all together and throughout the years contributed to a better insight in a syn...

OBJECTIVES Serotonin plays a central role in ejaculation and selective serotonin reuptake inhibitors have been successfully used to treat premature ejaculation. Here, we evaluated the relationship between a polymorphism in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the response of patients with premature ejaculation to SSRI medication. METHODS Sixty-nine premature...

Obtaining drugs for use in basic and preclinical research has become increasingly difficult and in many instances is dependent upon the company's interest in the proposed research. In this paper, we describe a simple procedure for extracting the antidepressants sertraline, paroxetine, fluoxetine, venlafaxine, citalopram, escitalopram, duloxetine and atomoxetine from their readily available phar...