نتایج جستجو برای: cisplatin toxicity

تعداد نتایج: 143067  

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2005
Xiaoliang Yan Richard A Gemeinhart

To develop a platform for tumor chemotherapy, poly(acrylic acid-co-methyl methacrylate) microparticles have been synthesized. Carboxylate containing monomers were included to complex therapeutic agents, specifically cisplatin. Microparticles were prepared by free radical emulsion polymerization in aqueous media. Particle diameter, zeta-potential, in vitro cytotoxicity, and in vivo acute toxicit...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Seiko Ishida Jaekwon Lee Dennis J Thiele Ira Herskowitz

Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. Molecular mechanisms that underlie cisplatin resistance are poorly understood. Here we demonstrate that deletion of the yeast CTR1 gene, which encodes a high-affinity copper transporter, results in increased cisplatin resista...

2006
Stephen B. Howell Craig E. Pfeifle Wally E. Wung Richard A. Olshen

The toxicity and pharmacokinetics of c/s-diamminedichloroplatinum (cisplatin) (90 mg/sq m) administered as a single 4hr peritoneal dialysis, with or without concurrent i.v. infusion of sodium thiosulfate, 0.43 or 2.13 g/sq m/hr for 12 hr, were studied on 20 courses of treatment. When given without thio sulfate, the toxicity of cisplatin was systemic rather than local, and the peritoneal cavity/...

2013
Dipali Dhawan Harsha Panchal Shilin Shukla Harish Padh

UNLABELLED background & objectives: The efficacy and toxicity of a given chemotherapy regimen varies widely among patients due to the inherited variability of genes that are involved in drug metabolism. There are several crucial enzymes identified involving metabolism of 5-fluorouracil (5-FU) and cisplatin, which are polymorphic. We studied head and neck cancer patients (n=23) on 5-FU and cispl...

2012
Hardeep S Oberoi Natalia V Nukolova Frederic C Laquer Larisa Y Poluektova Jiangeng Huang Yazen Alnouti Masanao Yokohira Lora L Arnold Alexander V Kabanov Samuel M Cohen Tatiana K Bronich

Polymer micelles with cross-linked ionic cores are shown here to improve the therapeutic performance of the platinum-containing anticancer compound cisplatin. Biodistribution, antitumor efficacy, and toxicity of cisplatin-loaded core cross-linked micelles of poly(ethylene glycol)-b-poly(methacrylic acid) were evaluated in a mouse ovarian cancer xenograft model. Cisplatin-loaded micelles demonst...

2011
Lihua Cheng Chengmeng Jin Wen Lv Qiuping Ding Xu Han

BACKGROUND Cisplatin is a potent anticancer drug, but its clinical application has been limited due to its undesirable physicochemical characteristics and severe side effects. Better drug formulations for cisplatin are highly desired. METHODOLOGY/PRINCIPAL FINDINGS Herein, we have developed a nanoparticle formulation for cisplatin with high encapsulation efficiency and reduced toxicity by usi...

Journal: :Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2014
Wilma Uyterlinde Chun Chen Jasper Nijkamp Marieke Groot Obbink Jan-Jakob Sonke Jose Belderbos Michel van den Heuvel

PURPOSE To test the hypothesis that daily intravenous pre-hydration decreases renal toxicity and improves chemotherapy adherence in patients receiving daily cisplatin to concurrent radiotherapy for locally advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS Patients with locally advanced NSCLC were treated between 2008 and August 2012 with daily 6 mg/m(2) cisplatin as a bolus in...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Wei-Hong Wei Xiu-Yu Cai Tao Xu Guo-Yi Zhang Yong-Feng Wu Wei-Neng Feng Li Lin Yan-Ming Deng Qiu-Xia Lu Zhe-Li Huang

BACKGROUND AND PURPOSE Cisplatin is the most common chemotherapeutic agent for loco-regionally advanced nasopharyngeal carcinoma (NPC); however, toxicity is a limiting factor for some patients. We retrospectively compared the efficacy and toxicity of weekly docetaxel-based and cisplatin-based concurrent chemoradiotherapy in loco-regionally advanced NPC. METHODS AND MATERIALS Eighty-four patie...

حاج‌زاده, موسی الرضا, حسینیان, سارا, خواجوی راد, ابوالفضل, شهرکی, سمیرا, محبتی, رضا, محمدیان روشن, نعما, ناجی ابراهیمی یزد, زهره,

Background and Objective: Cisplatin is one of the most important chemotherapy agents but its clinical use has been restricted due to nephrotoxicity. Nigella sativa (N.sativa) is an annual plant with many pharmacologic properties that has been used as a natural remedy for a number of illnesses. In the present study preventive and preventive-treatment effects of N.sativa extract was evaluated aga...

2007
Keun-Wook Lee Jee Hyun Kim Tak Yun Eun Kee Song Im il Na Hyunchoon Shin So Yeon Oh In Sil Choi Do-Youn Oh Dong-Wan Kim Seock-Ah Im Tae-You Kim Jong Seok Lee Dae Seog Heo Yung-Jue Bang Noe Kyeong Kim

This study was performed to evaluate the efficacy and toxicity of low-dose paclitaxel/cisplatin chemotherapy in patients with metastatic or recurrent gastric cancer that had failed 5-fluorouracil/platinum-based chemotherapy. Thirty-two patients with documented progression on or within 6 months after discontinuing 5-fluorouracil/platinum-based chemotherapy were enrolled. As a second-line treatme...

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