نتایج جستجو برای: cimetidine

تعداد نتایج: 1796  

Journal: :British medical journal 1984
S Walter J Thorup Andersen U Christensen H Løkkegaard H Kjersem J I Dahlager Jørgensen F Stadil

In 97 consecutive patients undergoing renal transplantation the incidence of upper gastrointestinal bleeding was registered over 180 days after allocation to treatment with either cimetidine or placebo. Bleeding episodes occurred in 12 patients, 11 of whom were receiving placebo and only one cimetidine (p less than 0.01). All bleeding episodes occurred during the first month after allotransplan...

Journal: :Japanese journal of pharmacology 1994
Y Morimoto K Shimohara K Tanaka H Hara T Sukamoto

Both KB-5492, a new anti-ulcer agent, and cimetidine, administered orally at 25-200 mg/kg, dose-dependently prevented cysteamine (400 mg/kg, s.c.)-induced duodenal ulcers in rats with ED50 values of 63 and 40 mg/kg, respectively. Anti-ulcer doses of cimetidine, but not KB-5492, inhibited gastric acid hypersecretion induced by cysteamine (400 mg/kg, s.c.). In contrast, anti-ulcer doses of KB-549...

Journal: :Cancer research 2000
K Kobayashi S Matsumoto T Morishima T Kawabe T Okamoto

Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated. In this report, we have demonstrated for the first time that cimetidine can block the adhesion of a colorectal tumor cell line to the endothelial cell monolayer in cell culture and that it can suppress the me...

Journal: :Gut 1979
M W Dronfield A J Batchelor W Larkworthy M J Langman

Forty-two patients with endoscopically diagnosed duodenal ulcer were studied in a double-blind trial after their ulcers had been healed with cimetidine. Cimetidine was effective in preventing relapse, only five of the 20 patients allocated to cimetidine 400 mg twice daily relapsing during the six months' treatment, compared with 16 of the 22 on placebo treatment (P less than 0.01). Cimetidine w...

Journal: :Oncology reports 2008
Koichiro Furuta Shuichi Sato Tatsuya Miyake Eisuke Okamoto Junichi Ishine Shunji Ishihara Yuji Amano Kyoichi Adachi Yoshikazu Kinoshita

Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear. We studied the anti-tumor effects of cimetidine on chemically-induced HCCs in rats. Four-week-old male Wistar rats (n=105) were divided into 4 groups. Those in groups A and B were administered diethylnitrosamine (DEN) intraperitoneally at 100...

Journal: :Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2007
Bhupinder Singh Kalra Sarita Aggarwal Nita Khurana Usha Gupta

OBJECTIVE To evaluate the hepatoprotective potential of cimetidine in hepatotoxicity induced by isoniazid-rifampicin combination in albino rabbits. METHODS Six groups of six rabbits each were studied. Three groups received saline (control), isoniazid (50 mg/Kg/d) alone or isoniazid with rifampicin (100 mg/Kg/d) daily orally for 7 days. Other groups received intraperitoneal cimetidine (50 mg/K...

Journal: :Gut 1989
F I Tovey E M Husband Y C Yiu L Baker G McPhail M R Lewin A P Jayaraj C G Clark

Forty six patients with endoscopically diagnosed duodenal ulceration were randomly allocated to treatment with either sucralfate 1 g qds (n = 24) or cimetidine 200 mg tds and 400 mg nocte (n = 22). When the ulcers healed, a maintenance dose of sucralfate 1 g bd or cimetidine 400 mg nocte was given for one year (or until relapse if earlier). Biopsies of duodenal mucosa adjacent to ulcer sites fo...

Journal: :Internal medicine 1994
T Horikoshi T Matsuzaki T Sekiguchi

The effect of the H2-receptor antagonists cimetidine and famotidine on interdigestive gastric motor activity and lower esophageal sphincter pressure was assessed in 41 patients with uncomplicated progressive systemic sclerosis. There was no significant change in gastric phasic motor activity after the intravenous administration of cimetidine (n = 6), famotidine (n = 13), and physiological salin...

2013
JA Sprowl L van Doorn S Hu L van Gerven P de Bruijn L Li AA Gibson RH Mathijssen A Sparreboom

The organic cation transporter 2 (OCT2) regulates uptake of cisplatin in proximal tubules, and inhibition of OCT2 protects against severe cisplatin-induced nephrotoxicity. However, it remains uncertain whether potent OCT2 inhibitors, such as cimetidine, can influence the antitumor properties and/or disposition of cisplatin. Using an array of preclinical assays, we found that cimetidine had no e...

Journal: :Indian journal of physiology and pharmacology 1987
S S Rao A Q Saifi

Ulcer formation after pylorus ligation was assessed in control, testosterone treated and castrated male rats after cimetidine treatment. The stomach was studied for incidence of ulcers and its contents analysed for pH, volume, total acidity, free acidity, pepsin and mucin activity. Testosterone and cimetidine when used alone protected from ulceration while when used in combination the degree of...

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