Chrysin is a bioactive flavonoid found in pollens, passion flowers, honey, royal jelly, and propolis, which commonly used as an ingredient natural food supplements primarily responsible for their pharmacological properties. A transparent chrysin-loaded microemulsion (CS-ME) prepared through ternary phase diagram was evaluated use antihyperalgesic formulation. It formulated with 40% Labrasol® (s...

Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavag...

Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective, and neuroprotective properties. The present study intends to investigate the geroprotective action of three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, Caenorhabditis elegans and Drosophila melanogaster. Luteolin and chrysin were sh...

Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render oral bioavailability rather poor. This study aimed to develop stable solid dispersion formulation of chrysin improve the dissolution chrysin, so as increase antihyperlipidemic A was prepared using solvent evaporation method, Plasdone® S630 hydrophilic carrier. The formulatio...

Propolis and its compounds have been the subject of many studies due to their antimicrobial and antiinflammatory activity; however, it is now known that they also possess antitumor properties. This review aims to summarize the results of studies on the mechanism of activity of propolis and its active compounds such as CAPE and chrysin in the apoptotic process, and their influence on the prolife...

Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored. In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative acti...