Egg surface applications of microliter quantities of crude and refined oils of high aromatic content are embryotoxic to mallards (Anas platyrhynchos) and other avian species; applications of aliphatic hydrocarbons have virtually no effect. Mallard eggs at 72 h of development were exposed to a mixture of aromatic hydrocarbons or to aromatic compounds representative to those present in crude oil ...

The DNA-binding properties of Ru(bpy)2(eilatin)(2+) have been investigated to determine if the sterically expansive eilatin ligand confers specificity for destabilized single-base mismatches in DNA. Competitive DNA photocleavage experiments employing a sequence-neutral metallointercalator, Rh(bpy)2(phi)(3+) (phi = 9,10-phenanthrenequinonediimine), and a mismatch-specific metalloinsertor, Rh(bpy...

Plasmodium falciparum is dangerous malarial species and most burdensome form of human malaria, affecting 200–300 million individuals per year worldwide, also because of its high rate of resistance outbreaks; there is a constant need for the discovery of novel antimalarials and drug targets. The three-dimensional structures of PFHGPRT, HSHGPRT and TCHGPRT were used for comparative docking study,...

The aim of this study was to analyze changes in the content of selected polycyclic aromatic hydrocarbons (PAHs) in urban soils fertilized with municipal sewage sludge. The factors in the experiment were three lawns along the main roads in Bialystok (in Popieluszki, Hetmanska and Raginisa Strs.), doses of sewage sludge (0 – control; 75 and 150 Mg/ha) and two years of study (2011 and 2012). The s...

polynuclear Aromatic Bydromrbons As criteria for the presence of polynuclear aromatic hydrocarbons in tobacco smoke, the list of J. W. Cook (m) has been widely accepted by tobacco chemists. The Surgeon General’s 1964 Report and Cook’s paper are in agreement with respect to the presence of benzo(a)pyrene (3 : 4benzopyrene) , dibenz (a,h) -anthracene (12 : 5,6-dibenzanthrac) : benzo(c) phenanthre...

the anti-carcinogenic activity of certain organic compounds, some of which are closely related to the carcinogenic hydrocarbons. Lacassagne et al. (2, 3) have reported that the addition of certain weak carcinogens to stronger ones will inhibit the carcinogenic activity of the latter when applied to the skin of mice. They studied the effects of 1,2,,5,6-dibenzofluorene and of chrysene when appli...

Specificities of murine glutathione (GSH) S-transferase (GST) isozymes mGSTA1-1, mGSTA2-2, mGSTA3-3 and mGSTA4-4 (alpha class), mGSTP1-1 (pi class) and mGSTM1-1 (mu class) for GSH conjugation of (-)-anti- and (+)-syn-stereoisomers of benzo[g]chrysene 11, 12-diol 13,14-epoxide (B[g]CDE), the activated metabolites of the environmental pollutant benzo[g]chrysene (B[g]C), have been determined. When...

The homogeneous 3 alpha-hydroxysteroid dehydrogenase (EC 1.1.1.50) of rat liver cytosol is indistinguishable from dihydrodiol dehydrogenase (trans-1,2-dihydrobenzene-1,2-diol dehydrogenase EC 1.3.1.20), Penning, T. M., Mukharji, I., Barrows, S., and Talalay, P. (1984) Biochem. J. 222, 601-611). Examination of the substrate specificity of the purified dehydrogenase for trans-dihydrodiol metaboli...